3-Bromopyruvate 7μM R04 exp175

Inhibits hexokinase II, pyruvate analog, enzyme alkylator, blocks glycolysis

PubChem Name: Bromopyruvic acid
Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP; Bromopyruvic acid;Hexokinase II Inhibitor II, 3-BP
CAS #: 1113-59-3
PubChem CID: 70684
IUPAC: 3-bromo-2-oxopropanoic acid
INCHI Name: InChI=1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
INCHI Key: PRRZDZJYSJLDBS-UHFFFAOYSA-N
Molecular Weight: 166.96
Canonical SMILES: C(C(=O)C(=O)O)Br
Isomeric SMILES: N/A
Molecular Formula: C3H3BrO3

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
21/50	Scores	View	View	View	View	View

Screen	Correlation	Plot
UM131593 0.2μM R03 exp106	0.096	View
Quercetin 20μM R08 exp517	0.087	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.081	View
TRAIL 50ng/ml R00 exp36	0.078	View
TRAIL 5ng/ml R00 exp35	0.075	View
Docosahexaenoic-acid 50μM R07 exp356	0.072	View
Dynasore 10μM R04 exp180	0.071	View
MK-1775 0.32μM R02 exp75	0.068	View
BML-284 0.09μM R08 exp460	0.064	View
Cryptotanshinone 12μM R05 exp227	0.063	View
LY2090314 0.003μM R08 exp499	0.058	View
UMK57 1μM R01 exp59	0.058	View
Olaparib 4μM R08 exp512	0.056	View
Aphidicolin 0.4μM R08 exp440	0.054	View
Dynasore 7μM R08 exp436	0.054	View
Bortezomib 0.005μM R00 exp6	0.053	View
Thimerosal 0.85μM R08 exp529	0.052	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.062	View

GO Term	Fold Change	Genes
GATOR1 complex	591.93	NPRL2,NPRL3
Seh1-associated complex	253.68	NPRL2,NPRL3,DEPDC5
negative regulation of TORC1 signaling	57.75	NPRL2,NPRL3,SZT2,DEPDC5
cellular response to amino acid starvation	49.33	NPRL2,NPRL3,SZT2,DEPDC5
response to amino acid starvation	46.43	NPRL2,NPRL3,SZT2,DEPDC5
negative regulation of TOR signaling	35.87	NPRL2,NPRL3,SZT2,DEPDC5
regulation of TORC1 signaling	27.53	NPRL2,NPRL3,SZT2,DEPDC5

GO Term	Fold Change	Genes
GATOR2 complex	276.23	WDR24,MIOS
CKM complex	276.23	MED13,CCNC
SAGA complex	138.12	SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
SAGA-type complex	87.23	SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
histone acetylation	57.15	TAF5L,KAT2A,SGF29
internal peptidyl-lysine acetylation	48.75	TAF5L,KAT2A,SGF29
histone acetyltransferase complex	42.97	BRPF1,SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
protein acetyltransferase complex	38.67	BRPF1,SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
acetyltransferase complex	38.29	BRPF1,SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
peptidase complex	27.86	SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
regulation of RNA splicing	18.83	SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
regulation of DNA repair	16.41	SUPT7L,TAF5L,TADA2B,TADA1,KAT2A,SGF29
transferase complex, transferring phosphorus-containing groups	13.71	TAF5L,POLR2J,MED13,KAT2A,CDK2,CCNC,PFKP
transcription coactivator activity	12.37	SUPT7L,TAF5L,TADA2B,TADA1,MED13,KAT2A
regulation of DNA metabolic process	9.83	SUPT7L,TAF5L,TADA2B,SLFN11,TADA1,ID3,KAT2A,CDK2,SGF29
transferase complex	8.67	FBXO11,BRPF1,SUPT7L,TAF5L,TADA2B,POLR2J,TADA1,MED13,KAT2A,CDK2,CCNC,SGF29,PFKP
transcription coregulator activity	7.94	SUPT7L,TAF5L,TADA2B,MED13L,TADA1,MED13,KAT2A
intracellular protein-containing complex	6.31	FBXO11,BRPF1,SUPT7L,TAF5L,MLST8,TADA2B,POLR2J,TADA1,KAT2A,SGF29
post-translational protein modification	5.61	FBXO11,UBA6,BIRC6,TAF5L,WDR24,KAT2A,CDK2,HECTD1,SGF29