BIRC6

Entrez Summary: N/A
UniProt Summary: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.26
Bortezomib 0.005μM R00 exp6	-2.05
Hippuristanol 0.12μM R08 exp488	-1.98
ZLN024 50μM R08 exp538	-1.77
Ribavirin 10 to 15μM on day4 R04 exp160	1.71
FBS-Wisent 0.1 R07 exp426	1.79
42°C R08 exp539	1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.89
THZ531 0.225μM R08 exp444	1.89
BI-6727 0.0125μM R03 exp97	1.97
Etoposide 0.1μM R05 exp198	2.05
GSK461364A 0.005μM R03 exp125	2.07
Tubastatin-A 2.5μM R07 exp417	2.12
Vincristine 0.0005μM R04 exp190	2.23
Rotenone 20μM R00 exp34	2.51
Menadione 5μM R06 exp292	2.73
Arsenate 40μM R06 exp264	3.6
3-Bromopyruvate 7μM R04 exp175	4.12

Global Fraction of Cell Lines Where Essential: 18/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	0/26
breast	5/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spongiotrophoblast layer development
Flemming body
cysteine-type endopeptidase inhibitor activity
ubiquitin conjugating enzyme activity
labyrinthine layer development
embryonic placenta development
regulation of cytokinesis
negative regulation of extrinsic apoptotic signaling pathway
spindle pole
placenta development
regulation of extrinsic apoptotic signaling pathway
midbody
microtubule organizing center
regulation of cell division
trans-Golgi network
negative regulation of apoptotic signaling pathway
negative regulation of endopeptidase activity
ubiquitin-protein transferase activity
negative regulation of peptidase activity
endosome
negative regulation of proteolysis
in utero embryonic development
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
reproductive structure development
reproductive system development
embryonic organ development
regulation of peptidase activity
negative regulation of hydrolase activity
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
protein catabolic process
protein ubiquitination