SEPHS1

Gene Information

Official Symbol: SEPHS1
Official Name: selenophosphate synthetase 1
Aliases and Previous Symbols: N/A
Entrez ID: 22929
UniProt: P49903
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Synthesizes selenophosphate from selenide and ATP. {ECO:0000269|PubMed:7665581}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-3.91
2-Methoxyestradiol 0.55μM R07 exp310	-3.86
BML-284 0.09μM R08 exp460	-3.69
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-3.59
Artemisinin 50μM R08 exp450	-3.58
Dynasore 10μM R04 exp180	-3.56
Taxol 0.004μM R03 exp103	-3.55
Mdivi-1 15μM R05 exp217	-3.48
Docosahexaenoic-acid 50μM R07 exp356	-3.28
BN82002 4μM R07 exp340	-3.2
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-3.19
Tenofovir 10μM R07 exp405	-3.16
Rifampicin 10μM R00 exp32	-3.13
UMK57 0.6μM R03 exp107	-3.04
Demecolcine 0.03μM R05 exp228	-3.01
Vincristine 0.0005μM R04 exp190	-2.95
Quercetin 20μM R08 exp517	-2.9
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.89
GSK626616 14μM R08 exp485	-2.87
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.76
Epigallocatechin gallate 20μM R05 exp230	-2.76
S-trityl-L-cysteine 0.5μM R05 exp243	-2.75
Bortezomib 0.005μM R00 exp6	-2.74
Nutlin-3A 1.6μM R06 exp294	-2.72
Wortmannin 5μM R00 exp38	-2.7
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.64
3-Bromopyruvate 7μM R04 exp175	-2.63
FK-506 5μM R07 exp358	-2.59
Lead acetate 2000μM R08 exp498 no dilution day6	-2.59
Amiloride 100μM R08 exp447	-2.47
Lead acetate 2000μM R08 exp497	-2.46
Disulfiram 4.3μM R06 exp281	-2.44
Sulforaphane 9μM R08 exp526 no dilution day6	-2.39
Lead acetate 990μM R08 exp496	-2.33
CAY10603 0.55μM R08 exp467	-2.31
Cryptotanshinone 12μM R05 exp227	-2.31
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.31
Radicicol 0.16μM R05 exp242	-2.3
Dimethyloxaloylglycine 11μM R07 exp314	-2.27
SNS-032 15μM R08 exp443	-2.26
Centrinone 0.5μM R07 exp343	-2.25
Metformin 100 to 150μM on day4 R04 exp170	-2.24
Selumetinib 20μM R02 exp81	-2.22
UMK57 1μM R01 exp59	-2.22
Alpha-Amanitin 0.5μM R00 exp5	-2.2
Cadmium 60μM R08 exp462	-2.17
UM0011500 5μM R05 exp245	-2.17
Ribavirin 10 to 15μM on day4 R04 exp160	-2.16
Menadione 5μM R06 exp292	-2.15
Wortmannin 0.5μM R00 exp37	-2.15
Thapsigargin 0.005μM R07 exp407	-2.14
Beta-Estradiol 0.55μM R07 exp425	-2.12
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.09
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.07
IU1-C 25μM R04 exp183	-2.04
Cabazitaxel 0.001μM R05 exp223	-2.02
Curcumin 6.5μM R06 exp277	-1.98
I-BRD9 4μM R07 exp365	-1.96
Trichostatin-A 0.06μM R07 exp415	-1.95
Dynasore 7μM R08 exp436	-1.94
JQ1 0.01μM R03 exp130	-1.94
Trametinib 10μM R02 exp83	-1.89
L-BMAA 500 to 750μM on day4 R04 exp185	-1.89
Apcin 50 to 100μM on day4 R04 exp176	-1.88
LJH685 50μM R08 exp433	-1.88
Docetaxel 0.002μM R01 exp45	-1.84
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.84
Rifampicin 1μM R00 exp31	-1.83
Diepoxybutane 3μM R07 exp354	-1.82
TGF-beta1 44ng/ml R08 exp528	-1.82
Chloramphenicol 2μM R00 exp12	-1.8
Talazoparib 0.006μM R06 exp299	-1.8
BH1 1μM R04 exp169	-1.79
CR131-b 0.005μM R08 exp474	-1.79
D-Fructose 10000μM R06 exp279	-1.78
HMS-I2 1μM R06 exp286	-1.76
Epothilone-B 0.0015μM R05 exp231	-1.75
BI-D1870 2μM R04 exp162	-1.72
Rifampicin 30μM R08 exp430	-1.72
CCCP 0.1μM R00 exp10	-1.71
Caffeine 2600μM R08 exp463	-1.7
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.7
TRAIL 5ng/ml R00 exp35	-1.7
Hinokiflavone 12μM R08 exp487	1.7
Resveratrol 16μM R03 exp147	1.71
SGC0946 7μM R03 exp151	1.72
Nocodazole 0.1μM R03 exp94	1.91
Fluvastatin 2.2μM R06 exp282	1.97
Bafilomycin-A1 0.009μM R08 exp454	2.11
Azithromycin 100μM R08 exp452	2.26
MS023 2μM R03 exp134	2.35

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17493
Expression level (log2 read counts): 6.89

Expression Distribution

Gene	Correlation
QRICH1	0.651
TACC3	0.501
DLGAP5	0.468
ASPM	0.436
CALM2	0.421

AIRS C
AIRS

tRNA seleno-modification
selenocysteine biosynthetic process
selenide, water dikinase activity
selenocysteine metabolic process
selenium compound metabolic process
serine family amino acid biosynthetic process
serine family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
alpha-amino acid metabolic process
nuclear membrane
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
ncRNA processing
GTP binding
ncRNA metabolic process
small molecule biosynthetic process
RNA processing
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
phosphorylation
organonitrogen compound biosynthetic process
ATP binding
RNA metabolic process
small molecule metabolic process
gene expression