Pimelic-diphenylamide-106 0.5μM R00 exp27 [The Human Chemical-Genetic Interaction Map Project]

Inhibits HDAC3 selectively, benzamide derivative

Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Compound References

PubChem Name: Pimelic Diphenylamide 106
Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII
CAS #: 937039-45-7
PubChem CID: 16070100
IUPAC: N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide
INCHI Name: InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
INCHI Key: WTKBRPXPNAKVEQ-UHFFFAOYSA-N
Molecular Weight: 339.4
Canonical SMILES: CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
Isomeric SMILES: N/A
Molecular Formula: C20H25N3O2

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: SML0313
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H25N3O2 340.20195; found 340.20313

Dose Response Curve

Platform ID: PD106
Min: -5.1320; Max: 91.7728

IC	Concentration (µM)
IC10	N/A
IC20	0.7702
IC30	1.0245
IC40	1.2946
IC50	1.6046
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 00
Dose: 500nM
Days of incubation: 8
Doublings: 6.2
Numbers of reads: 11779532

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/3	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
QRICH1	-2.95	0.04
ASB3	-2.91	0.03
DCAF15	-2.62	0.11
PRAMEF25	-2.55	0.54
PRAMEF26	-2.54	0.54
STAG2	-2.52	0.11
ADK	-2.48	0.11
RPP30	-2.46	0.11
PDCD5	-2.45	0.11
RABIF	-2.41	0.11
DDX20	-2.40	0.11
SEPHS1	-2.31	0.11
CDIPT	-2.26	0.35
GFPT1	-2.23	0.34
KHDRBS1	-2.09	0.36
ZNHIT1	-2.08	0.34
TAF1B	-2.08	0.36
WT1	-2.07	0.34
RPE	-2.07	0.36
CUL2	-2.06	0.36
PMM2	-2.05	0.34
WDR61	-2.05	0.40
PEX1	-2.04	0.34
CTC1	-2.03	0.36
GEMIN5	-2.02	0.34
TCF4	-2.01	0.34
RAB36	-2.01	0.34
TRMT44	-2.01	0.34
TTC39A	-2.00	0.36
FCGR3B	-1.99	0.36
MYH2	2.04	0.48
NDC80	2.04	0.52
MSH3	2.05	0.35
BIRC3	2.06	0.35
ORC6	2.07	0.45
TFIP11	2.08	0.36
COPE	2.09	0.48
PLEKHA4	2.09	0.35
SUPT6H	2.10	0.51
KIR3DL3	2.11	0.35
SULT2B1	2.13	0.35
OR6C68	2.15	0.28
TRA2B	2.18	0.37
RFFL	2.19	0.35
CNKSR2	2.21	0.25
STAMBPL1	2.24	0.23
TRAPPC2L	2.24	0.23
ATP2C1	2.28	0.23
RPL34	2.28	0.48
PROCA1	2.28	0.28
RPL37	2.29	0.48
TPX2	2.52	0.37
RPL7L1	2.57	0.23
THAP5	2.66	0.05
OR1L1	2.69	0.05
NSA2	2.79	0.33
POLE	2.79	0.37
OR52D1	2.89	0.08
KIF11	3.30	0.35
DEFB114	3.62	0.05

Screen	Correlation	Plot
Rifampicin 1μM R00 exp31	0.084	View
Wortmannin 0.5μM R00 exp37	0.073	View
Nocodazole 0.02μM R00 exp23	0.067	View
Cycloheximide 0.02μM R00 exp14	0.065	View
Alpha-Amanitin 0.5μM R00 exp5	0.06	View
Doxycycline 10μM R00 exp18	0.056	View
5-Fluorouracil 2μM R00 exp1	0.053	View

Last modified: 2026/01/15 21:36
by 127.0.0.1