DCAF15

Gene Information

Official Symbol: DCAF15
Official Name: DDB1 and CUL4 associated factor 15
Aliases and Previous Symbols: N/A
Entrez ID: 90379
UniProt: Q66K64
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase. {ECO:0000269|PubMed:16949367}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-3.2
Selumetinib 20μM R02 exp81	-3.07
Wortmannin 0.5μM R00 exp37	-2.92
IU1-47 25μM R04 exp182	-2.89
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.62
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.62
5-Fluorouracil 2μM R00 exp1	-2.53
GSK626616 14μM R08 exp485	-2.49
PFI-2 4μM R05 exp239	-2.37
DABN 2μM R00 exp16	-2.28
Rapamycin 1μM R00 exp29	-2.27
SGC2043 10μM R03 exp152	-2.27
BN82002 4μM R07 exp340	-2.23
Trametinib 10μM R02 exp83	-2.2
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.15
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.13
Demecolcine 0.03μM R05 exp228	-2.13
Rifampicin 10μM R00 exp32	-2.13
HMS-I2 5μM R06 exp287	-2.12
Colchicine 0.009μM R05 exp215	-2.08
TNF-alpha 44ng/ml R08 exp533	-2.07
Benzoate 10000μM R08 exp455	-2.01
Cycloheximide 0.2μM R00 exp15	-2
LB-100 4.1μM R02 exp72	-1.98
FTY720 3μM R08 exp483	-1.94
Docetaxel 0.002μM R01 exp45	-1.93
Taxol 0.004μM R03 exp103	-1.92
Prochlorperazine 5.2μM R02 exp77	-1.9
Metformin 100 to 150μM on day4 R04 exp170	-1.89
MK2206 4μM R08 exp504	-1.89
Dimethyloxaloylglycine 100μM R05 exp229	-1.88
Apcin 25μM plus proTAME 2μM R04 exp177	-1.87
Rapamycin 2μM R07 exp306	-1.87
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.83
CB-839 10μM R05 exp224	-1.83
Isoniazid 100μM R08 exp494	-1.83
Momordin-Ic 10μM R08 exp506	-1.83
Temozolomide 200μM R04 exp189	-1.81
Hypoxia 5%O2 R04 exp191	-1.8
Cadmium 60μM R08 exp462	-1.74
Pyrazinamide 100μM R08 exp516	-1.73
EPZ-5676 30μM R05 exp233	-1.7
Aminopterin 0.005μM R07 exp335	2.02
Monensin 0.3μM R08 exp507	2.2
ML-792 0.2μM R08 exp505	2.65

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4191
Expression level (log2 read counts): 5.76

Expression Distribution

Gene	Correlation
ASB3	0.505
URM1	0.413
DEDD	0.403

Cul4-RING E3 ubiquitin ligase complex
protein-containing complex
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal