IU1-47 25μM R04 exp182

Inhibits USP14, enhances protein degradation by 26S proteasome

PubChem Name: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one
Synonyms: N/A
CAS #: 670270-31-2
PubChem CID: 675477
IUPAC: 1-[1-(4-chlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone
INCHI Name: InChI=1S/C19H23ClN2O/c1-14-12-18(19(23)13-21-10-4-3-5-11-21)15(2)22(14)17-8-6-16(20)7-9-17/h6-9,12H,3-5,10-11,13H2,1-2H3
INCHI Key: VXQIPRWKLACSKZ-UHFFFAOYSA-N
Molecular Weight: 330.8
Canonical SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)Cl)C)C(=O)CN3CCCCC3
Isomeric SMILES: N/A
Molecular Formula: C19H23ClN2O

Supplier Name: In house - Harvard Medical School - Daniel Finley group - Synthesized as described in Boselli and al., 2017
Catalog #: N/A
Lot #: N/A

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
8/0	Scores	View	View	View	View	View

Screen	Correlation	Plot
Thioridazine 5μM R08 exp530	0.079	View
SGC0946 7μM R03 exp151	0.071	View
Wiskostatin 3μM R07 exp422	0.067	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.066	View
ZLN024 50μM R08 exp538	0.061	View
Q15 1 to 2μM on day4 R04 exp164	0.061	View
L-74142 5μM R03 exp131	0.054	View
Ibrutinib 10μM R08 exp442	0.053	View
Chlorpromazine 10μM R07 exp344	0.062	View
BH1 1μM R04 exp169	0.061	View
CAY10603 0.55μM R08 exp467	0.061	View
BS-181 20μM R08 exp461	0.053	View
FTY720 3μM R08 exp483	0.052	View
B02 10μM R08 exp453	0.051	View