PKD1L3

Official Symbol: PKD1L3
Official Name: polycystin 1 like 3, transient receptor potential channel interacting
Aliases and Previous Symbols: N/A
Entrez ID: 342372
UniProt: Q7Z443
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009].
UniProt Summary: Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:12782129, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 40μM R07 exp334	-1.71
Dynasore 7μM R08 exp436	1.91
NN-Diethyl-meta-toluamide 500μM R08 exp438	2.01
IU1-47 25μM R04 exp182	2.25

Expression Distribution

GPS
PLAT

detection of chemical stimulus involved in sensory perception of sour taste
sour taste receptor activity
sensory perception of sour taste
cation transmembrane transporter activity
cation channel complex
cellular response to acidic pH
cation channel activity
response to acidic pH
cellular response to pH
response to pH
detection of mechanical stimulus
detection of chemical stimulus involved in sensory perception of taste
calcium channel activity
sensory perception of taste
detection of external stimulus
detection of abiotic stimulus
carbohydrate binding
calcium ion transmembrane transport
receptor complex
response to mechanical stimulus
calcium ion transport
kidney development
renal system development
divalent metal ion transport
divalent inorganic cation transport
cellular response to environmental stimulus
cellular response to abiotic stimulus
urogenital system development
detection of chemical stimulus involved in sensory perception
detection of chemical stimulus
sensory perception of chemical stimulus
detection of stimulus involved in sensory perception
inorganic cation transmembrane transport
cation transmembrane transport
cell surface
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
cation transport
ion transmembrane transport