SLC25A32

Entrez Summary: This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013].
UniProt Summary: Transports folate across the inner membranes of mitochondria.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-3.52
Ibrutinib 1μM R07 exp372	-2
MK-1775 0.32μM R02 exp75	-1.94
Wortmannin 5μM R00 exp38	1.72
Cannabidiol 13μM R08 exp465	1.75
CyclicAMP 200μM R08 exp475	1.79
Salubrinal 20μM R07 exp399	1.81
BI-D1870 3.15μM R02 exp66	1.84
HMS-I2 5μM R06 exp287	1.84
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.84
Arsenic trioxide 60μM R08 exp449	1.85
Trientine 500μM R08 exp534	1.86
Rotenone 0.07μM R08 exp431	1.88
Bortezomib 0.005μM R00 exp6	1.89
Bafilomycin-A1 0.009μM R08 exp454	1.9
3-Bromopyruvate 7μM R04 exp175	1.91
Chloramphenicol 20μM R00 exp13	1.94
CCCP 0.1μM R00 exp10	1.95
Sulforaphane 9μM R08 exp526 no dilution day6	1.95
Rapamycin 10μM R00 exp30	1.96
Deguelin 0.15μM R05 exp209	1.97
Deguelin 0.05μM R02 exp69	2
Arsenate 40μM R06 exp264	2.05
Selumetinib 20μM R02 exp81	2.12
CCCP 1μM R00 exp11	2.13
Chlorpromazine 10μM R07 exp344	2.13
iCRT14 30μM R08 exp492	2.14
Senexin-A 25μM R07 exp400	2.15
IU1-47 25μM R04 exp182	2.16
QNZ 0.01μM R05 exp241	2.24
Nutlin-3A 1.6μM R06 exp294	2.26
Rucaparib 6.5μM R08 exp520	2.26
BS-181 20μM R08 exp461	2.3
CB-839 10μM R05 exp224	2.41
Bisphenol A 100μM R06 exp269	2.49
Rifampicin 1μM R00 exp31	2.5
Hypoxia 5%O2 R04 exp191	2.59
Artemisinin 50μM R08 exp450	3.12
UM0131023 0.05μM R05 exp248	3.14
Citral 50μM R06 exp274	3.29
AICAR 240μM R03 exp116	5.3
AICAR 240μM R05 exp211	6.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

folate import into mitochondrion
FAD transmembrane transporter activity
FAD transmembrane transport
folic acid transmembrane transporter activity
folate transmembrane transport
nucleotide transmembrane transport
folic acid transport
vitamin transmembrane transport
glycine metabolic process
folic acid metabolic process
nucleotide transport
modified amino acid transport
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
vitamin transport
serine family amino acid metabolic process
cofactor transport
drug transmembrane transport
dicarboxylic acid transport
water-soluble vitamin metabolic process
neurotransmitter metabolic process
mitochondrial transmembrane transport
dicarboxylic acid metabolic process
organophosphate ester transport
vitamin metabolic process
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
mitochondrial transport
nucleobase-containing compound transport
coenzyme metabolic process
anion transmembrane transport
carboxylic acid transport
organic acid transport
cellular amino acid metabolic process
regulation of neurotransmitter levels
mitochondrial inner membrane
cofactor metabolic process