Deguelin 0.05μM R02 exp69
Mechanism of Action
Derivative of rotenone, putative AKT inhibitor, complex I inhibitor
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
- Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor
Technical Notes
Compound References
- PubChem Name: Deguelin
- Synonyms: (-)-Deguelin; (-)-cis-Deguelin
- CAS #: 522-17-8
- PubChem CID: 107935
- IUPAC: (1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one
- INCHI Name: InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1
- INCHI Key: ORDAZKGHSNRHTD-UXHICEINSA-N
- Molecular Weight: 394.4
- Canonical SMILES: CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC)C
- Isomeric SMILES: CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C
- Molecular Formula: C23H22O6
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: D0817
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H22O6 395.14891; found 395.1502
Dose Response Curve
- Platform ID: Deguelin
- Min: -2.5150; Max: 50.5961
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 02
- Dose: 50nM
- Days of incubation: 8
- Doublings: 6.3
- Numbers of reads: 9193347
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Deguelin 0.05μM R02 exp69
