HIPK3

Gene Information

Official Symbol: HIPK3
Official Name: homeodomain interacting protein kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 10114
UniProt: Q9H422
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14441
Expression level (log2 read counts): 6.23

Expression Distribution

Pkinase Tyr
Pkinase

negative regulation of JUN kinase activity
mRNA transcription
negative regulation of JNK cascade
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
peptidyl-threonine phosphorylation
regulation of JUN kinase activity
protein tyrosine kinase activity
peptidyl-threonine modification
PML body
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
peptidyl-serine phosphorylation
regulation of JNK cascade
peptidyl-serine modification
negative regulation of protein kinase activity
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
nuclear body
regulation of MAP kinase activity
protein serine/threonine kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity