PRPS1

Entrez Summary: This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
UniProt Summary: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-3.8
CHIR-124 0.04μM R06 exp272	-3.21
Ribavirin 10μM R01 exp52	-3.2
Ribavirin 10 to 15μM on day4 R04 exp160	-3.11
LY2090314 0.003μM R08 exp499	-3.08
Vemurafenib 6.6μM R02 exp89	-2.89
Radicicol 0.16μM R05 exp242	-2.72
LY2090314 0.003μM R08 exp500 no dilution day6	-2.7
VE-822 0.04μM R06 exp300	-2.61
Temozolomide 200μM R04 exp189	-2.16
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.11
Rapamycin 10μM R00 exp30	-2.11
BI-2536 0.0042μM R03 exp95	-2.04
TRAIL 5ng/ml R00 exp35	-2.04
BH1 1μM R04 exp169	-1.98
Vemurafenib 6.6μM R08 exp434	-1.94
Caffeine 2600μM R08 exp463	-1.9
KU-0063794 3.8μM R02 exp71	-1.83
GSK626616 14μM R08 exp485	-1.78
CB-5083 0.4μM R08 exp468	-1.76
Talazoparib 0.006μM R06 exp299	-1.75
UMK57 1μM R01 exp59	-1.72
Nutlin-3A 1.6μM R06 exp294	1.7
Betulinic acid 10 to 15μM on day4 R05 exp222	1.71
AICAR 240μM R03 exp116	1.72
Nifuroxazide 1μM R01 exp51	1.73
Trientine 500μM R08 exp534	1.74
Chloramphenicol 20μM R00 exp13	1.76
LLY-283 2.6μM R06 exp290	1.8
BVD-523 15μM R02 exp67	1.88
Mubritinib 0.2μM R02 exp65	1.9
RS-1 10μM R08 exp519	1.94
NMS-873 0.07μM R07 exp380	2
Mubritinib 0.2μM R01 exp48	2.15
Citral 50μM R06 exp274	2.31
Phenformin 20μM R03 exp143	2.37
Hypoxia 5%O2 R04 exp191	2.57
UM0131023 0.05μM R05 exp248	2.58
Deguelin 0.05μM R02 exp69	2.7
AICAR 240μM R05 exp211	2.73
QNZ 0.01μM R05 exp241	2.91
IU1-C 25μM R04 exp183	3.12
Nifuroxazide 5μM R03 exp102	4.82

Global Fraction of Cell Lines Where Essential: 3/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/26
bone	0/26
breast	1/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

urate biosynthetic process
hypoxanthine biosynthetic process
hypoxanthine metabolic process
ribose phosphate diphosphokinase complex
ribose phosphate diphosphokinase activity
5-phosphoribose 1-diphosphate metabolic process
5-phosphoribose 1-diphosphate biosynthetic process
purine nucleobase biosynthetic process
urate metabolic process
nucleobase biosynthetic process
purine nucleobase metabolic process
ribonucleoside monophosphate biosynthetic process
nucleobase metabolic process
nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pigment biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
pigment metabolic process
nucleoside monophosphate metabolic process
kinase activity
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
purine nucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
magnesium ion binding
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process