CHIR-124 0.04μM R06 exp272
Mechanism of Action
Inhibits CHK1, blocks checkpoint arrest, potentiates DNA damaging agents
- Class / Subclass 1: DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor
- Class / Subclass 2: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: 4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One
- Synonyms: N/A
- CAS #: 405168-58-3
- PubChem CID: 135399748
- IUPAC: 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one
- INCHI Name: InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1
- INCHI Key: MOVBBVMDHIRCTG-LJQANCHMSA-N
- Molecular Weight: 419.9
- Canonical SMILES: C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5
- Isomeric SMILES: C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5
- Molecular Formula: C23H22ClN5O
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-13263
- Lot #: 10573
Compound Characterization
Characterization data not available.
Dose Response Curve
- Platform ID: CHIR-124
- Min: 10.7944; Max: 99.8850
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | 0.0221 |
| IC40 | N/A |
| IC50 | 0.0515 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 40nM
- Days of incubation: 8
- Doublings: 7.3
- Numbers of reads: 9391802
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
CHIR-124 0.04μM R06 exp272
