CACNA2D3

Official Symbol: CACNA2D3
Official Name: calcium voltage-gated channel auxiliary subunit alpha2delta 3
Aliases and Previous Symbols: N/A
Entrez ID: 55799
UniProt: Q8IZS8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MLN-4924 0.2μM R00 exp21	-1.84
CHIR-124 0.04μM R06 exp272	1.9

voltage-gated calcium channel complex
voltage-gated calcium channel activity
cardiac conduction
multicellular organismal signaling
calcium ion transmembrane transport
regulation of heart contraction
calcium ion transport
regulation of blood circulation
divalent metal ion transport
divalent inorganic cation transport
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
regulation of transport