UPF2

Entrez Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-3.04
Tozasertib 0.1μM R07 exp414	-2.69
Etoposide 0.3μM R05 exp199	-2.55
CHIR-124 0.04μM R06 exp272	-2.07
HMS-I1 10μM R06 exp256	-2.07
Bisphenol F 50μM R08 exp457	-2
Ethanol 0.01 R05 exp234	-2
MS023 7μM R03 exp135	-2
Citral 75μM R06 exp275	-1.94
FK-506 30μM R07 exp359	-1.94
Rotenone 0.07μM R08 exp431	-1.84
Milciclib 2μM R08 exp502	-1.83
Dorsomorphin 5μM R07 exp357	-1.82
Cryptotanshinone 12μM R05 exp227	-1.8
Palbociclib 1μM R07 exp382	-1.71
Rucaparib 6.5μM R08 exp520	-1.7
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.73
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.74
Rifampicin 1μM R00 exp31	1.77
TRAIL 5ng/ml R00 exp35	1.87
YM155 0.001μM R08 exp432	2.1
Selumetinib 20μM R02 exp81	2.11
Dimethyl-Sulfoxide 1pc R03 exp120	2.44

Global Fraction of Cell Lines Where Essential: 557/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	18/28
blood	21/28
bone	21/26
breast	19/33
central nervous system	39/56
cervix	4/4
colorectal	13/17
esophagus	10/13
fibroblast	1/1
gastric	9/16
kidney	14/21
liver	12/20
lung	55/75
lymphocyte	15/16
ovary	22/26
pancreas	21/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	16/24
soft tissue	9/9
thyroid	1/2
upper aerodigestive	17/22
urinary tract	23/29
uterus	3/5

Expression Distribution

MIF4G
Upf2

exon-exon junction complex
telomeric DNA binding
polysome
cytoplasmic ribonucleoprotein granule
animal organ regeneration
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
liver development
RNA export from nucleus
hepaticobiliary system development
protein export from nucleus
mRNA transport
regeneration
nuclear export
RNA transport
nucleic acid transport
establishment of RNA localization
nuclear-transcribed mRNA catabolic process
RNA localization
mRNA catabolic process
nucleobase-containing compound transport
RNA catabolic process
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
nucleobase-containing compound catabolic process
gland development
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
mRNA metabolic process
perinuclear region of cytoplasm
cellular macromolecule catabolic process
intracellular protein transport
macromolecule catabolic process
RNA binding