FK-506 30μM R07 exp359
Mechanism of Action
Inhibits calcineurin
- Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor
Technical Notes
Compound References
- PubChem Name: Tacrolimus
- Synonyms: FK506; Fujimycin; FR900506
- CAS #: 104987-11-3
- PubChem CID: 445643
- IUPAC: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
- INCHI Name: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
- INCHI Key: QJJXYPPXXYFBGM-LFZNUXCKSA-N
- Molecular Weight: 804
- Canonical SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
- Isomeric SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
- Molecular Formula: C44H69NO12
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: F370000
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C44H69NO12 826.4712; found 826.47365
Dose Response Curve
- Platform ID: FK-506
- Min: -17.1824; Max: 93.4566
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 29.9866 |
| IC30 | 31.6841 |
| IC40 | 33.1471 |
| IC50 | 34.5490 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 30µM
- Days of incubation: 8
- Doublings: 4.2
- Numbers of reads: 20870386
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 21/8 | Scores |
FK-506 30μM R07 exp359
FK-506 30μM R07 exp359 vs Pterostilbene 16μM R02 exp78
FK-506 30μM R07 exp359 vs Ibrutinib 10μM R08 exp442
FK-506 30μM R07 exp359 vs WYE-354 6μM R02 exp90
FK-506 30μM R07 exp359 vs iCRT14 30μM R08 exp492
FK-506 30μM R07 exp359 vs Milciclib 2μM R08 exp502
FK-506 30μM R07 exp359 vs Thioridazine 5μM R08 exp530
FK-506 30μM R07 exp359 vs UM0129480 7μM R02 exp85
FK-506 30μM R07 exp359 vs Lead acetate 2000μM R08 exp497
FK-506 30μM R07 exp359 vs Lead acetate 2000μM R08 exp498 no dilution day6
FK-506 30μM R07 exp359 vs MK-1775 0.32μM R02 exp75
Cryptotanshinone 12μM R05 exp227 vs FK-506 30μM R07 exp359
Bisphenol A 100μM R06 exp269 vs FK-506 30μM R07 exp359
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs FK-506 30μM R07 exp359
B02 10μM R08 exp453 vs FK-506 30μM R07 exp359
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs FK-506 30μM R07 exp359
CB-839 10μM R05 exp224 vs FK-506 30μM R07 exp359
Amiloride 100μM R08 exp447 vs FK-506 30μM R07 exp359
BVD-523 15μM R02 exp67 vs FK-506 30μM R07 exp359
Chlorpromazine 10μM R07 exp344 vs FK-506 30μM R07 exp359
2-Deoxy-D-glucose 800μM R05 exp214 vs FK-506 30μM R07 exp359
