BHLHB9

Gene Information

Official Symbol: BHLHB9
Official Name: basic helix-loop-helix family member b9
Aliases and Previous Symbols: N/A
Entrez ID: 80823
UniProt: Q6PI77
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011].
UniProt Summary: May play a role in the control of cellular aging and survival.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13455
Expression level (log2 read counts): 2.08

Expression Distribution

Screen	Score
FBS-Wisent 0.1 R07 exp426	1.98
FK-506 30μM R07 exp359	2.11
Trichostatin-A 0.06μM R07 exp415	2.55

positive regulation of dendritic spine morphogenesis
positive regulation of dendrite morphogenesis
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
positive regulation of synapse assembly
positive regulation of dendrite development
regulation of dendritic spine development
regulation of dendrite morphogenesis
regulation of postsynapse organization
regulation of synapse assembly
negative regulation of neuron apoptotic process
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
regulation of neuron apoptotic process
negative regulation of neuron death
regulation of synapse organization
regulation of synapse structure or activity
learning or memory
positive regulation of neuron projection development
cognition
regulation of cell morphogenesis involved in differentiation
regulation of neuron death
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of cellular component biogenesis
positive regulation of nervous system development
positive regulation of cell development
behavior
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
protein homodimerization activity
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of nervous system development
regulation of cell development