DERL2

Gene Information

Official Symbol: DERL2
Official Name: derlin 2
Aliases and Previous Symbols: N/A
Entrez ID: 51009
UniProt: Q9GZP9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-3.86
All-trans-Retinoic-Acid 40μM R07 exp334	-3.79
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-3.52
iCRT14 30μM R08 exp492	-3.5
Dimethyloxaloylglycine 100μM R05 exp229	-3.12
Golgicide-A 4μM R03 exp122	-3.08
Trametinib 10μM R02 exp83	-2.86
Ethanol 0.01 R05 exp234	-2.83
Cyclosporin-A 0.8μM R07 exp347	-2.82
FK-506 30μM R07 exp359	-2.81
Benzoate 10000μM R08 exp455	-2.76
MK2206 4μM R08 exp504	-2.63
Rapamycin 10μM R00 exp30	-2.58
Milciclib 2μM R08 exp502	-2.53
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.52
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.49
CB-5083 0.4μM R08 exp468	-2.35
All-trans-Retinoic-Acid 8μM R07 exp333	-2.27
Pyridostatin 4μM R05 exp240	-2.23
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.23
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.23
Bisphenol A 100μM R06 exp269	-2.15
Pterostilbene 16μM R02 exp78	-2.13
Fluvastatin 2.2μM R06 exp282	-2.07
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.06
LLY-283 2.6μM R06 exp290	-2.03
Tunicamycin 0.04μM R07 exp418	-1.98
Chlorpromazine 10μM R07 exp344	-1.95
Lapatinib 5μM R01 exp47	-1.95
Tubacin 1.6μM R07 exp416	-1.9
Cadmium 60μM R08 exp462	-1.85
Calcium Ionophore 0.4μM R07 exp342	-1.83
Cannabidiol 20μM R08 exp466	-1.82
Cyclosporin-A 3μM R07 exp348	-1.82
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.81
Erlotinib 10μM R05 exp216	-1.8
ETC-159 50μM R08 exp480	-1.78
Rapamycin 2μM R07 exp306	-1.78
Hydroxyurea 15μM R06 exp289	-1.76
Oligomycin-A 2μM R00 exp25	-1.75
Fas-L 44ng/ml R08 exp482	-1.74
HMS-I2 5μM R06 exp287	-1.73
LY2090314 0.003μM R08 exp500 no dilution day6	-1.72
UM0125461 0.74μM R02 exp84	-1.71
A-395 10μM R05 exp218	-1.7
EPZ-5676 30μM R05 exp233	-1.7
Radicicol 0.16μM R05 exp242	-1.7
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.76
ML-792 0.2μM R08 exp505	1.82
MLN-4924 0.2μM R00 exp21	2.27
42°C R08 exp539	2.95

Gene	Correlation
UBE2J1	0.602
MANF	0.602
DNAJC3	0.563
UBE2G2	0.504
ALG5	0.499
CCDC101	0.496
DERL1	0.492
ENY2	0.468
GMPPB	0.468
XPO6	0.464
GTF3C2	0.453
CBFB	0.436
SLC35B1	0.435
DNAJB11	0.43
GTF2I	0.426
MED16	0.421
DPAGT1	0.421
EIF4E	0.418
NXT1	0.418
MAPK14	0.417
RNMT	0.414
TMED10	0.411
RPTOR	0.411
C1orf27	0.41
VMP1	0.409
DAD1	0.403
MAX	0.402
TMEM41B	0.401

Global Fraction of Cell Lines Where Essential: 55/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	1/28
blood	5/28
bone	2/26
breast	2/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	3/21
liver	4/20
lung	3/75
lymphocyte	3/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1850
Expression level (log2 read counts): 5.74

Expression Distribution

signal recognition particle receptor complex
signal recognition particle
Hrd1p ubiquitin ligase ERAD-L complex
negative regulation of retrograde protein transport, ER to cytosol
negative regulation of protein exit from endoplasmic reticulum
negative regulation of ERAD pathway
regulation of retrograde protein transport, ER to cytosol
suckling behavior
endoplasmic reticulum mannose trimming
ubiquitin-specific protease binding
endoplasmic reticulum to cytosol transport
retrograde protein transport, ER to cytosol
protein demannosylation
protein alpha-1,2-demannosylation
endoplasmic reticulum quality control compartment
protein exit from endoplasmic reticulum
misfolded protein binding
regulation of protein exit from endoplasmic reticulum
regulation of ERAD pathway
protein deglycosylation
negative regulation of intracellular protein transport
negative regulation of response to endoplasmic reticulum stress
negative regulation of proteasomal protein catabolic process
negative regulation of intracellular transport
multi-organism behavior
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of response to endoplasmic reticulum stress
feeding behavior
negative regulation of cellular protein catabolic process
ERAD pathway
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
negative regulation of cellular protein localization
late endosome
cellular response to unfolded protein
negative regulation of protein catabolic process
cellular response to topologically incorrect protein
response to unfolded protein
positive regulation of cell growth