GTF2I

Entrez Summary: This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-2.36
Lead acetate 2000μM R08 exp497	-2.15
Bortezomib 0.005μM R00 exp6	-1.88
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.87
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.83
Tunicamycin 0.04μM R07 exp418	-1.81
Radicicol 0.16μM R05 exp242	-1.8
Cyclosporin-A 3μM R07 exp348	-1.79
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.74
Trientine 500μM R08 exp534	-1.71
Lead acetate 2000μM R08 exp498 no dilution day6	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of cytosolic calcium ion concentration
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
regulation of angiogenesis
regulation of vasculature development
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
transcription by RNA polymerase II
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
transcription, DNA-templated
nucleic acid-templated transcription
cellular ion homeostasis
RNA biosynthetic process
DNA-binding transcription factor activity
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
negative regulation of developmental process
regulation of anatomical structure morphogenesis
nucleobase-containing compound biosynthetic process
chemical homeostasis
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of multicellular organismal process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
homeostatic process
RNA metabolic process
cellular macromolecule biosynthetic process