Hydroxyurea 15μM R06 exp289
Mechanism of Action
Inhibits ribonucleotide reductase, scavenges tyrosyl radicals
- Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor
- Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor
Technical Notes
Compound References
- PubChem Name: Hydroxyurea
- Synonyms: Hydroxycarbamide
- CAS #: 127-07-1
- PubChem CID: 3657
- IUPAC: hydroxyurea
- INCHI Name: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
- INCHI Key: VSNHCAURESNICA-UHFFFAOYSA-N
- Molecular Weight: 76.055
- Canonical SMILES: C(=O)(N)NO
- Isomeric SMILES: N/A
- Molecular Formula: CH4N2O2
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: H8627
- Lot #: MKBK3764V
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for CH4N2O2 77.03455; found 77.03325
Dose Response Curve
- Platform ID: Hydroxyurea
- Min: 15.1964; Max: 85.9305
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | 2.1781 |
| IC40 | N/A |
| IC50 | 45.0127 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 15µM
- Days of incubation: 8
- Doublings: 7.0
- Numbers of reads: 8591149
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Hydroxyurea 15μM R06 exp289
