DDX54

Entrez Summary: N/A
UniProt Summary: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 704/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	24/25
breast	32/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	19/21
liver	20/20
lung	74/75
lymphocyte	14/14
ovary	25/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	21/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	5/5

Expression Distribution

Gene	Correlation
HGC6.3	0.44
TCEB3CL2	0.418

intracellular estrogen receptor signaling pathway
estrogen receptor binding
RNA helicase activity
intracellular steroid hormone receptor signaling pathway
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
rRNA processing
rRNA metabolic process
transcription corepressor activity
ribosome biogenesis
response to steroid hormone
signaling receptor binding
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
response to lipid
nucleolus
RNA processing
response to hormone
response to organic cyclic compound
Golgi apparatus
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
response to endogenous stimulus
ATP binding
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
RNA metabolic process
membrane
gene expression