DDX54 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX54
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 54
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79039|79039]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDD1|Q8TDD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611665|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DBP10CT|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular estrogen receptor signaling pathway|
|estrogen receptor binding|
|RNA helicase activity|
|intracellular steroid hormone receptor signaling pathway|
|steroid hormone mediated signaling pathway|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|rRNA processing|
|rRNA metabolic process|
|transcription corepressor activity|
|ribosome biogenesis|
|response to steroid hormone|
|signaling receptor binding|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|response to lipid|
|nucleolus|
|RNA processing|
|response to hormone|
|response to organic cyclic compound|
|Golgi apparatus|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.82|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.4|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.92|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.88|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.71|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.7|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.7|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.75|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.75|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.77|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.77|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.84|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.93|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.96|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.97|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.04|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.08|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.44|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 704/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|24/25|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|19/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX54 Expression in NALM6 Cells: 7.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>