SGC0649 7μM R03 exp150 [The Human Chemical-Genetic Interaction Map Project]

Inactive control for SGC0649 (DOT1L methyltransferase inhibitor)

Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Compound References

PubChem Name: N/A
Synonyms: N/A
CAS #: N/A
PubChem CID: N/A
IUPAC: N/A
INCHI Name: N/A
INCHI Key: N/A
Molecular Weight: 603.56
Canonical SMILES: N/A
Isomeric SMILES: N/A
Molecular Formula: C28H39N6O4Br

Compound Supplier

Supplier Name: Structural Genomics Consortium
Catalog #: N/A
Lot #: N/A

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C28H39BrN6O4 603.22889; found 603.22937

Dose Response Curve

Platform ID: SGC0649
Min: -7.3456; Max: 19.7209

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 7µM
Days of incubation: 8
Doublings: 8.1
Numbers of reads: 11099781

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
PCDHGA11	-2.76	0.22
GCLC	-2.46	0.37
DPAGT1	-2.45	0.45
ENO1	-2.44	0.45
RALGAPA2	-2.35	0.37
SNAPC5	-2.21	0.45
RAB1B	-2.17	0.45
FEN1	-2.16	0.45
PUS1	-2.16	0.45
CCNB3	-2.15	0.45
PDK3	-2.14	0.45
SEC16A	-2.11	0.62
EIF3M	-2.10	0.45
PRAMEF10	-2.06	0.45
LOC403312	-2.04	0.59
RAB24	-2.03	0.45
PYROXD1	-2.02	0.82
LMX1B	-2.00	0.62
MICU3	-1.99	0.49
PRR14L	-1.98	0.62
NDRG4	-1.97	0.51
PIK3C3	-1.96	0.62
PRTG	-1.92	0.59
FDPS	-1.92	0.72
HBP1	-1.90	0.62
CCDC155	-1.88	0.65
ITGB8	-1.88	0.65
MNAT1	-1.88	0.65
GRIN2B	-1.86	0.62
DRD5	-1.86	0.67
SORCS1	1.91	0.62
NDC80	1.91	0.86
CCDC94	1.91	0.84
CACNA1E	1.93	0.62
MARS	1.93	0.75
TRIM37	1.95	0.60
NPRL3	1.95	0.83
TCTN2	1.95	0.72
NSF	1.97	0.72
NGLY1	1.98	0.55
UTP11L	1.99	0.72
DLX2	2.00	0.55
DDX54	2.04	0.72
USP11	2.04	0.51
KIDINS220	2.10	0.51
PSMC4	2.15	0.72
HOXA13	2.16	0.51
RANBP2	2.16	0.51
ZNF841	2.23	0.49
CAB39	2.24	0.51
STK38	2.24	0.55
APBA1	2.27	0.51
USP39	2.30	0.51
CFHR4	2.39	0.38
NPIPB3	2.44	0.72
HSPE1	2.47	0.63
RARS	2.80	0.72
TMSB15B	3.02	0.51
PRPF18	3.06	0.44
PLK4	3.28	0.38

Last modified: 2026/01/15 21:36
by 127.0.0.1