APBA1

Entrez Summary: N/A
UniProt Summary: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP- beta.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloramphenicol 2μM R00 exp12	-1.84
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.8
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.23
SB202190 10μM R03 exp148	2.27
SGC0649 7μM R03 exp150	2.27
GSK343 3μM R03 exp124	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PID
PDZ

gamma-aminobutyric acid secretion
gamma-aminobutyric acid transport
presynaptic active zone membrane
glutamate secretion
acidic amino acid transport
axo-dendritic transport
regulation of synaptic vesicle exocytosis
dicarboxylic acid transport
acid secretion
amyloid-beta binding
multicellular organism growth
Schaffer collateral - CA1 synapse
signal release from synapse
neurotransmitter secretion
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
amino acid transport
synaptic vesicle
monocarboxylic acid transport
regulation of neurotransmitter transport
dendritic spine
transport along microtubule
regulation of regulated secretory pathway
signal release
cytoskeleton-dependent intracellular transport
neurotransmitter transport
microtubule-based transport
locomotory behavior
regulation of exocytosis
synapse
microtubule-based movement
carboxylic acid transport
organic acid transport
glutamatergic synapse
regulation of neurotransmitter levels
in utero embryonic development
developmental growth
growth
anterograde trans-synaptic signaling
chemical synaptic transmission