SB202190 10μM R03 exp148 [The Human Chemical-Genetic Interaction Map Project]

Inhibits p38‘± (MAPK14)and p38‘_ (MAPK11) kinase, ATP competitive

Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
Synonyms: N/A
CAS #: 152121-30-7
PubChem CID: 5169
IUPAC: 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
INCHI Name: InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
INCHI Key: QHKYPYXTTXKZST-UHFFFAOYSA-N
Molecular Weight: 331.3
Canonical SMILES: C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
Isomeric SMILES: N/A
Molecular Formula: C20H14FN3O

Compound Supplier

Supplier Name: Selleck Chemicals
Catalog #: S1077
Lot #: 01

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H14FN3O 332.11937; found 332.11933

Dose Response Curve

Platform ID: SB202190
Min: 4.3648; Max: 53.7816

IC	Concentration (µM)
IC10	N/A
IC20	2.7330
IC30	7.9975
IC40	19.2844
IC50	43.2506
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 10µM
Days of incubation: 8
Doublings: 6.9
Numbers of reads: 10145836

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
2/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SLC5A3	-3.94	<0.01
KDSR	-3.66	<0.01
QARS	-2.85	0.32
GPR107	-2.54	0.10
ETV3	-2.47	0.18
HMBS	-2.38	0.18
RGP1	-2.36	0.27
KCNK13	-2.33	0.18
EXTL1	-2.30	0.49
ALAD	-2.30	0.21
SUCLA2	-2.26	0.18
CNTNAP5	-2.26	0.18
RABGGTB	-2.25	0.25
TMEM186	-2.25	0.18
SLC47A1	-2.24	0.18
MOCS3	-2.24	0.31
SLC38A1	-2.20	0.20
KIAA1432	-2.16	0.21
ANKRD36B	-2.12	0.30
RUNDC1	-2.08	0.27
ATP5H	-2.07	0.27
PGGT1B	-2.06	0.28
FECH	-2.04	0.29
NUDT22	-2.02	0.46
WDR20	-2.02	0.30
SAFB	-2.01	0.35
ZDHHC23	-2.01	0.30
CCDC47	-2.01	0.30
C6orf118	-2.00	0.54
PABPC1L	-2.00	0.46
PFN2	1.92	0.56
ZNF791	1.92	0.56
NUP133	1.92	0.56
ASH1L	1.93	0.56
TIMM44	1.94	0.63
CLEC1B	1.95	0.56
RGL3	1.96	0.56
ATRX	1.97	0.56
GLTSCR2	1.99	0.64
TCERG1	2.00	0.60
PES1	2.01	0.63
TRIM49B	2.02	0.56
ANKRD55	2.03	0.56
PSMB7	2.03	0.56
CNOT4	2.03	0.50
ARRDC3	2.05	0.56
MIA2	2.09	0.50
WNT5A	2.11	0.50
IPPK	2.13	0.50
ERG	2.14	0.50
GGA3	2.16	0.50
TMEM232	2.21	0.50
APBA1	2.27	0.50
FDPS	2.29	0.50
MMP15	2.29	0.45
SUGT1	2.29	0.56
IDE	2.34	0.50
NOP16	2.39	0.74
RPS23	2.44	0.28
MAPK1	2.49	0.28

GO Term	Fold Change	Genes
protein geranylgeranyltransferase activity	318.83	RABGGTB,PGGT1B
protein geranylgeranylation	255.06	RABGGTB,PGGT1B
protoporphyrinogen IX metabolic process	191.30	HMBS,ALAD,FECH
porphyrin-containing compound biosynthetic process	91.09	HMBS,ALAD,SUCLA2,FECH
tetrapyrrole biosynthetic process	91.09	HMBS,ALAD,SUCLA2,FECH
heme biosynthetic process	76.52	HMBS,ALAD,FECH
porphyrin-containing compound metabolic process	55.45	HMBS,ALAD,SUCLA2,FECH
tetrapyrrole metabolic process	47.23	HMBS,ALAD,SUCLA2,FECH

Last modified: 2026/01/15 21:36
by 127.0.0.1