SLC47A1

Entrez Summary: N/A
UniProt Summary: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.2μM R02 exp64	-2.38
SB202190 10μM R03 exp148	-2.24
Dynasore 10μM R04 exp180	-1.85
SNS-032 25μM R07 exp401	-1.83
UNC1999 2μM R03 exp155	-1.8
Methotrexate 0.01μM R08 exp501	-1.76
Nicotinamide 2000μM R01 exp50	-1.73
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.71
Benzoate 10000μM R08 exp455	1.74
SGC0649 7μM R03 exp150	1.85
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.89
LJH685 50μM R08 exp433	1.91
QNZ 0.01μM R08 exp439	1.92
THZ531 0.11μM R07 exp409	2.1
Lapatinib 5μM R01 exp47	2.22
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.62

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

xenobiotic transmembrane transporter activity
xenobiotic transport
antiporter activity
organic cation transport
drug transmembrane transport
vesicle
drug transport
cation transport
response to drug
transmembrane transport
ion transport