SLC47A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC47A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC47A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 47 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55244|55244]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FL8|Q96FL8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC47A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC47A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MatE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|xenobiotic transmembrane transporter activity|
|xenobiotic transport|
|antiporter activity|
|organic cation transport|
|drug transmembrane transport|
|vesicle|
|drug transport|
|cation transport|
|response to drug|
|transmembrane transport|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.38|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.24|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.85|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.83|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.8|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.76|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.73|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.71|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.74|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.85|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.89|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.91|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.92|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.1|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.22|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16994
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC47A1 Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>