CLEC1B

Entrez Summary: N/A
UniProt Summary: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). {ECO:0000269|PubMed:18215137, ECO:0000269|PubMed:18955485}. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507). {ECO:0000305|PubMed:16940507}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LJH685 50μM R08 exp433	1.81
SB202190 10μM R03 exp148	1.95

platelet formation
platelet morphogenesis
transmembrane signaling receptor activity
platelet activation
carbohydrate binding
myeloid cell differentiation
blood coagulation
coagulation
hemostasis
signal transduction by protein phosphorylation
wound healing
regulation of body fluid levels
hemopoiesis
cell morphogenesis involved in differentiation
response to wounding
hematopoietic or lymphoid organ development
immune system development
cell morphogenesis
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
protein phosphorylation
cell activation
phosphorylation
defense response
integral component of plasma membrane
cell development