CCDC47

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-2.73
QNZ 0.01μM R08 exp439	-2.33
Clomiphene 4.4μM R02 exp68	-2.23
Mubritinib 0.2μM R01 exp48	-2.11
EPZ-5676 30μM R05 exp233	-2.02
SB202190 10μM R03 exp148	-2.01
Rifampicin 1μM R00 exp31	-1.99
proTAME 5μM R04 exp187	-1.94
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.91
Citral 75μM R06 exp275	-1.88
Azithromycin 100μM R08 exp452	-1.84
THZ531 0.225μM R08 exp444	-1.77
Citral 50μM R06 exp274	-1.72
Cryptotanshinone 12μM R05 exp227	-1.72
BI-6727 0.04μM R03 exp98	1.72
GSK591 2.6μM R03 exp128	1.74
UM0011500 10μM R05 exp246	1.75
3-Bromopyruvate 7μM R04 exp175	1.79
Latrunculin-B 10μM R07 exp374	1.9
Bleomycin 5μM R08 exp459	2.02
Tunicamycin 0.04μM R07 exp418	2.15
Arsenate 40μM R06 exp264	2.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ER overload response
ER-nucleus signaling pathway
endoplasmic reticulum organization
rough endoplasmic reticulum
ubiquitin-dependent ERAD pathway
post-embryonic development
ERAD pathway
osteoblast differentiation
cellular response to biotic stimulus
response to endoplasmic reticulum stress
ossification
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
endomembrane system organization
calcium ion homeostasis
divalent inorganic cation homeostasis
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
metal ion homeostasis
protein catabolic process
cation homeostasis
inorganic ion homeostasis
calcium ion binding
ion homeostasis
cellular macromolecule catabolic process
response to organonitrogen compound
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
chemical homeostasis
proteolysis
response to biotic stimulus
RNA binding
homeostatic process
cellular response to stress
organic substance catabolic process