PGGT1B

Gene Information

Official Symbol: PGGT1B
Official Name: protein geranylgeranyltransferase type I subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 5229
UniProt: P53609
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:8106351}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 1μM R06 exp286	-3.1
ETC-159 50μM R08 exp480	-2.77
proTAME 5μM R04 exp187	-2.6
SB203580 25μM R03 exp149	-2.58
All-trans-Retinoic-Acid 8μM R07 exp333	-2.56
Wortmannin 5μM R00 exp38	-2.56
LY2090314 0.003μM R08 exp500 no dilution day6	-2.55
Nocodazole 0.02μM R00 exp23	-2.53
CAY10603 0.55μM R08 exp467	-2.51
Pomalidomide 20μM R07 exp391	-2.46
UM0011500 5μM R05 exp245	-2.4
Wortmannin 0.5μM R00 exp37	-2.4
Citral 50μM R06 exp274	-2.38
Ethanol 0.01 R05 exp234	-2.26
Nicotinamide Riboside 100μM R03 exp139	-2.24
Resminostat 0.5μM R07 exp393	-2.23
Apcin 50 to 100μM on day4 R04 exp176	-2.17
Wiskostatin 3μM R07 exp422	-2.16
Trientine 500μM R08 exp534	-2.11
Losmapimod 1μM R07 exp376	-2.09
SB202190 10μM R03 exp148	-2.06
CCT251545 0.2μM R06 exp271	-2.01
BH1 1μM R04 exp169	-1.99
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.99
LY2090314 0.003μM R08 exp499	-1.98
MSC2530818 10μM R07 exp379	-1.97
SGC2096 2.6μM R03 exp153	-1.96
DABN 2μM R00 exp16	-1.95
Metformin 100 to 150μM on day4 R04 exp170	-1.95
Geldanamycin 0.01μM R05 exp235	-1.94
Zebularine 20μM R07 exp423	-1.93
UM0125461 0.74μM R02 exp84	-1.92
Cyclosporin-A 3μM R07 exp348	-1.91
BI-6727 0.0125μM R03 exp97	-1.88
Dynasore 7μM R08 exp436	-1.88
NFN1 0.1μM R01 exp49	-1.87
Pyridostatin 4μM R05 exp240	-1.87
RO-3306 3 to 4μM on day4 R04 exp165	-1.86
A-769662 20μM R07 exp331	-1.85
Trichostatin-A 0.06μM R07 exp415	-1.83
Apcin 25μM plus proTAME 2μM R04 exp177	-1.78
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.76
Cincreasin 100μM R08 exp473	-1.76
Selumetinib 20μM R02 exp81	-1.75
Dynasore 10μM R04 exp180	-1.73
S-DABN 8μM R03 exp112	-1.73
Benzoate 10000μM R08 exp455	-1.72
Parthenolide 2.5μM R05 exp238	-1.72
All-trans-Retinoic-Acid 40μM R07 exp334	-1.71
Rifampicin 30μM R08 exp430	-1.71
CHIR-124 0.04μM R06 exp272	-1.7
Tanespimycin 14μM R08 exp527	1.73
Salinomycin 3.5μM R08 exp521	1.83
Amiloride 100μM R08 exp447	1.85
CI-1040 9.5μM R08 exp472	1.86
Nicotine 3000μM R08 exp510	2.15
Vitamin-D3 40μM R08 exp536	2.26
42°C R08 exp539	2.7
THZ531 0.225μM R08 exp444	2.76
Arsenate 40μM R06 exp264	4.26

Gene	Correlation
ALG5	0.541
PMM2	0.536
TAZ	0.503
AARS	0.501
GTF3C6	0.5
TRIAP1	0.497
SRP14	0.491
TAMM41	0.489
ALG1	0.472
ATXN10	0.47
DHRSX	0.466
SEC62	0.466
THG1L	0.459
DPAGT1	0.458
ALG6	0.455
UAP1	0.453
HARS	0.448
MRPS33	0.447
CHCHD4	0.446
RTCB	0.444
YARS2	0.441
RPP21	0.439
UHRF1	0.438
PPA2	0.437
GFPT1	0.436
UBE2G2	0.436
RNMT	0.432
GTF3C4	0.428
PPCS	0.425
VEZT	0.424
NAE1	0.423
ATP5A1	0.423
SRD5A3	0.423
GMPPB	0.421
MRPS34	0.419
RPE	0.419
UTP23	0.418
CRLS1	0.418
GEMIN7	0.416
ADSL	0.416
MED16	0.416
TEN1	0.416
SUPV3L1	0.415
CBFB	0.414
LSM10	0.414
PPP4C	0.413
ALG13	0.413
MRPS18A	0.412
MBTPS2	0.41
DPF2	0.41
FH	0.409
DOLK	0.409
RPIA	0.407
MRPS6	0.405
TIMM13	0.405
DNLZ	0.405
TMEM41B	0.404
VARS2	0.404
CCDC101	0.403
TAF1A	0.402
PELO	0.401
ATP5B	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4501
Expression level (log2 read counts): 4.83

Expression Distribution

isoprenoid binding
CAAX-protein geranylgeranyltransferase complex
CAAX-protein geranylgeranyltransferase activity
protein geranylgeranyltransferase activity
negative regulation of nitric-oxide synthase biosynthetic process
protein geranylgeranylation
protein prenylation
prenylation
regulation of nitric-oxide synthase biosynthetic process
peptide binding
drug binding
positive regulation of cell cycle
zinc ion binding
positive regulation of cell population proliferation
response to cytokine
regulation of cell cycle
negative regulation of macromolecule biosynthetic process
negative regulation of biosynthetic process
regulation of cell population proliferation