Losmapimod 1μM R07 exp376
Mechanism of Action
Inhibits p38‘±/‘_ MAP kinases
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: Losmapimod
- Synonyms: GSK-AHAB; GW856553X; SB856553
- CAS #: 585543-15-3
- PubChem CID: 11552706
- IUPAC: 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- INCHI Name: InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
- INCHI Key: KKYABQBFGDZVNQ-UHFFFAOYSA-N
- Molecular Weight: 383.5
- Canonical SMILES: CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C
- Isomeric SMILES: N/A
- Molecular Formula: C22H26FN3O2
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S7215
- Lot #: S721 501
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H26FN3O2 384.20818; found 384.20948
Dose Response Curve
- Platform ID: Losmapimod
- Min: -20.8875; Max: -2.4013
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 1µM
- Days of incubation: 8
- Doublings: 7.1
- Numbers of reads: 22591304
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Losmapimod 1μM R07 exp376
Losmapimod 1μM R07 exp376 vs VHL-ligand-1 20μM R07 exp421
