IQCG

Entrez Summary: N/A
UniProt Summary: Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250|UniProtKB:Q80W32, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R05 exp212	-1.91
CFI-400945 25μM R08 exp469	-1.74
Ibrutinib 1μM R07 exp372	1.78
All-trans-Retinoic-Acid 40μM R07 exp334	1.83
Losmapimod 1μM R07 exp376	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

manchette
sperm axoneme assembly
Hsp70 protein binding
sperm flagellum
axoneme assembly
sperm motility
flagellated sperm motility
microtubule bundle formation
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
spermatid development
spermatid differentiation
calmodulin binding
germ cell development
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation
organelle assembly
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell motility
localization of cell
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
reproductive process
reproduction
movement of cell or subcellular component