PDE2A
Gene Information
- Official Symbol: PDE2A
- Official Name: phosphodiesterase 2A
- Aliases and Previous Symbols: N/A
- Entrez ID: 5138
- UniProt: O00408
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PDEase I |
| GAF |
GO Terms
| cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity |
| response to 2,3,7,8-tetrachlorodibenzodioxine |
| cGMP catabolic process |
| negative regulation of cGMP-mediated signaling |
| cellular response to cGMP |
| response to cGMP |
| cellular response to macrophage colony-stimulating factor stimulus |
| TPR domain binding |
| response to macrophage colony-stimulating factor |
| positive regulation of vascular permeability |
| phosphate ion binding |
| negative regulation of vascular permeability |
| 3,5-cyclic-AMP phosphodiesterase activity |
| cyclic nucleotide catabolic process |
| regulation of cGMP-mediated signaling |
| cGMP binding |
| 3,5-cyclic-GMP phosphodiesterase activity |
| cGMP metabolic process |
| negative regulation of cAMP-mediated signaling |
| cAMP binding |
| cGMP-mediated signaling |
| purine ribonucleotide catabolic process |
| establishment of endothelial barrier |
| ribonucleotide catabolic process |
| regulation of vascular permeability |
| cyclic nucleotide metabolic process |
| purine nucleotide catabolic process |
| regulation of cAMP-mediated signaling |
| endothelial cell development |
| aorta development |
| purine-containing compound catabolic process |
| calcium channel activity |
| cellular response to cAMP |
| drug binding |
| heart valve development |
| nucleotide catabolic process |
| ventricular septum development |
| nucleoside phosphate catabolic process |
| presynaptic membrane |
| cellular response to mechanical stimulus |
| endothelial cell differentiation |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| artery development |
| endothelium development |
| response to cAMP |
| nucleobase-containing small molecule biosynthetic process |
| cardiac septum development |
| cardiac ventricle development |
| organophosphate catabolic process |
| response to organophosphorus |
| positive regulation of inflammatory response |
| cAMP-mediated signaling |
| response to purine-containing compound |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| mitochondrial outer membrane |
| vascular process in circulatory system |
| cardiac chamber development |
| cyclic-nucleotide-mediated signaling |
| regulation of mitochondrion organization |
| cellular response to xenobiotic stimulus |
| epithelial cell development |
| carbohydrate derivative catabolic process |
| calcium ion transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| response to mechanical stimulus |
| magnesium ion binding |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| calcium ion transport |
| divalent metal ion transport |
| response to xenobiotic stimulus |
| divalent inorganic cation transport |
| purine ribonucleotide metabolic process |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| cellular response to external stimulus |
| regulation of inflammatory response |
| second-messenger-mediated signaling |
| purine-containing compound metabolic process |
| mitochondrial matrix |
| nucleobase-containing compound catabolic process |
| blood circulation |
| circulatory system process |
| mitochondrial inner membrane |
| cellular response to drug |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| positive regulation of defense response |
| organic cyclic compound catabolic process |
| blood vessel development |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| vasculature development |
| cardiovascular system development |
| heart development |
| response to growth factor |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| inorganic cation transmembrane transport |
| small molecule biosynthetic process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| metal ion transport |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| epithelial cell differentiation |
| perinuclear region of cytoplasm |
| regulation of defense response |
| cation transport |
| zinc ion binding |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| organophosphate metabolic process |
| response to organic cyclic compound |
| ion transmembrane transport |
| Golgi apparatus |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| response to drug |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| epithelium development |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| transmembrane transport |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| cell development |
| intracellular signal transduction |
| negative regulation of gene expression |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Losmapimod 1μM R07 exp376 | -1.9 |
| 5-Azacytidine 2μM R07 exp330 | -1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11468
- Expression level (log2 read counts): -0.61
Expression Distribution
PDE2A Expression in NALM6 Cells: -0.61
