YARS2

Gene Information

Official Symbol: YARS2
Official Name: tyrosyl-tRNA synthetase 2
Aliases and Previous Symbols: N/A
Entrez ID: 51067
UniProt: Q9Y2Z4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011].
UniProt Summary: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000269|PubMed:15779907, ECO:0000269|PubMed:17997975}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-2.3
Isonicotinamide 500μM R03 exp129	-1.92
Myriocin 25μM R06 exp293	-1.89
BH1 1μM R04 exp169	-1.78
GSK-J5 1.5μM R08 exp484	-1.74
PFI-2 4μM R05 exp239	-1.74
Azithromycin 100μM R08 exp452	1.78
Phenformin 20μM R03 exp143	1.78
Rotenone 0.07μM R08 exp431	1.83
RK-33 8μM R08 exp518	1.85
PU-H71 1μM R08 exp515	1.88
BML-284 0.09μM R08 exp460	1.93
CR131-b 0.005μM R08 exp474	2.01
Deferoxamine 11μM R07 exp350	2.04
UM131593 0.2μM R03 exp106	2.04
Tanespimycin 14μM R08 exp527	2.05
TIC10 10μM R08 exp532	2.06
ONC212 0.15μM R08 exp513	2.1
Mubritinib 0.2μM R02 exp65	2.14
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.16
Artemisinin 50μM R08 exp450	2.2
iCRT14 30μM R08 exp492	2.21
Monensin 0.3μM R08 exp507	2.21
Amiloride 100μM R08 exp447	2.34
Atovaquone 15μM R08 exp451	2.34
Arsenate 40μM R06 exp264	2.34
LLY-283 2.6μM R06 exp290	2.44
Vemurafenib 6.6μM R08 exp434	2.44
Oligomycin-A 2μM R00 exp25	2.56
CI-1040 9.5μM R08 exp472	2.66
UM0125461 0.74μM R02 exp84	2.72
Hydroxyurea 100μM R07 exp329	2.83
GSK-J4 1.5μM R08 exp441	2.93
Thimerosal 0.85μM R08 exp529	3.2
Aphidicolin 0.4μM R08 exp440	3.68

Gene	Correlation
HSD17B10	0.771
TARS2	0.761
NARS2	0.756
MRPS6	0.756
DAP3	0.753
MRPS21	0.748
MRPL23	0.74
MRPS14	0.738
SELRC1	0.736
PARS2	0.735
MRPS5	0.734
SCO2	0.733
MRPL21	0.731
RPUSD4	0.73
VARS2	0.73
MRPS34	0.727
EARS2	0.722
GFM1	0.718
QRSL1	0.717
LARS2	0.711
MRPS16	0.707
MRPS26	0.699
BCS1L	0.697
RBFA	0.692
TEFM	0.687
COX16	0.681
DARS2	0.679
FASTKD5	0.676
RARS2	0.674
SARS2	0.673
MRPL53	0.672
MRPL47	0.672
MRP63	0.671
MARS2	0.667
GATC	0.663
C10orf2	0.662
RNASEH1	0.661
KIAA0391	0.66
SUPV3L1	0.654
MRPL12	0.644
FTSJ2	0.643
PET112	0.643
WBSCR16	0.641
NDUFB11	0.64
COA3	0.639
NDUFAF7	0.637
C17orf89	0.636
MRPS18A	0.635
HARS2	0.632
NDUFA3	0.625
TUFM	0.625
MRPS25	0.621
MTPAP	0.621
MTG2	0.618
MRPL20	0.613
TRUB2	0.612
SLC25A26	0.612
COA6	0.611
TOMM20	0.61
AARS2	0.61
MRPS24	0.608
C12orf65	0.608
MRPS12	0.607
FARS2	0.606
POLG	0.597
DHRSX	0.597
GTPBP10	0.597
MRPL15	0.596
GFM2	0.593
COX7B	0.592
COX15	0.591
MRPS33	0.59
POLG2	0.588
MRPS10	0.587
PNPT1	0.587
COX11	0.585
MRPL34	0.583
MRPS2	0.581
MRPL45	0.575
MRPS9	0.573
MTRF1L	0.572
TMEM242	0.572
MTERFD2	0.571
TRMT61A	0.571
ATP5A1	0.571
MRPL33	0.568
MRPL11	0.566
PDSS1	0.565
NDUFA1	0.563
MRPL3	0.558
MRPS11	0.554
NDUFB5	0.554
METTL17	0.551
RPUSD3	0.551
MTG1	0.551
WARS2	0.55
MRPL42	0.549
MRPS23	0.546
ALDH18A1	0.545
PGM3	0.544
MRPL44	0.543
NDUFC2	0.542
COX17	0.541
COX5A	0.54
FH	0.539
MRPL43	0.539
ATP5D	0.538
POLRMT	0.536
AIFM1	0.533
UQCR10	0.533
MRPL55	0.533
MRPS35	0.532
MRPL4	0.531
ELAC2	0.529
DNLZ	0.528
RTN4IP1	0.527
TFAM	0.527
COX6C	0.527
NDUFA2	0.526
ATP5SL	0.525
TRIAP1	0.525
CHCHD4	0.523
ATP5C1	0.52
CARS2	0.519
MRPL41	0.518
MRPL36	0.518
PET117	0.514
RNMTL1	0.514
ALG6	0.514
MRPL18	0.513
NDUFB6	0.512
PPCS	0.511
TMEM126B	0.51
MIPEP	0.509
MRPS22	0.508
UQCRC2	0.508
LSM10	0.508
NDUFB9	0.503
PPA2	0.503
COQ3	0.501
MRPS17	0.501
TPK1	0.5
TOMM22	0.5
ATP5B	0.499
HIGD2A	0.499
NDUFS7	0.498
DHX30	0.497
COQ2	0.496
TOMM40	0.494
IBA57	0.494
THG1L	0.493
RPIA	0.492
GTPBP6	0.489
PTDSS1	0.489
NDUFA10	0.488
NDUFS2	0.487
MRPS27	0.486
PMVK	0.486
COQ7	0.486
MRPL22	0.485
TIMM8B	0.484
TRMT10A	0.482
MRPL39	0.482
NDUFAF3	0.481
NDUFB3	0.481
ECSIT	0.481
COX20	0.48
MALSU1	0.479
MRPS7	0.479
MTERFD1	0.479
NDUFAF4	0.478
MRPL2	0.478
TFB1M	0.476
ALG8	0.475
MRPL27	0.474
TAMM41	0.474
LRPPRC	0.474
NDUFA11	0.473
PET100	0.473
UQCRQ	0.472
AASDHPPT	0.471
GRSF1	0.471
SRD5A3	0.471
MRPL35	0.471
ACAD9	0.471
MTIF3	0.47
ATXN10	0.47
PMM2	0.47
KDSR	0.469
PPCDC	0.468
OPA1	0.466
SSB	0.466
DDX28	0.465
PITRM1	0.465
MTIF2	0.465
TMEM261	0.462
NDUFV1	0.459
COA5	0.459
NDUFB1	0.459
HCCS	0.459
TRMT10C	0.457
ATP5O	0.455
MRPL17	0.455
DOHH	0.455
MCAT	0.454
MRPL46	0.454
DPAGT1	0.452
ATP5H	0.45
ATP5J	0.45
COQ6	0.45
MRPL52	0.45
NFU1	0.449
NDUFAF5	0.449
HMGXB3	0.448
COX6B1	0.448
ALAS1	0.447
MRPL13	0.447
SEC62	0.446
FAM195A	0.445
NDUFAF1	0.444
ALG1	0.444
ROMO1	0.443
MRPL51	0.443
RPE	0.442
PGGT1B	0.441
UQCC2	0.441
PTCD1	0.441
TIMMDC1	0.441
UAP1	0.441
PTCD3	0.439
FOXRED1	0.439
GTPBP8	0.436
COX19	0.434
CHCHD1	0.434
CRLS1	0.433
PTPMT1	0.433
SLC25A3	0.433
MRPL37	0.431
SLC25A19	0.431
DOLK	0.428
MRPL49	0.427
MTO1	0.427
NDUFA8	0.427
C1QBP	0.424
ALG13	0.423
ATIC	0.42
TEN1	0.419
MBTPS2	0.419
UHRF1	0.419
ATP5L	0.419
PRKRIR	0.419
VEZT	0.419
MRPS28	0.418
MRPL38	0.418
GLRX5	0.417
SSBP1	0.417
COQ5	0.416
SRP14	0.416
NDUFS5	0.415
MRPL1	0.415
GTF3C6	0.414
NOA1	0.413
MTRF1	0.412
MINOS1	0.412
NDUFC1	0.412
ATP5E	0.411
METTL1	0.409
TAZ	0.409
CLPP	0.408
NDUFS1	0.408
ERAL1	0.408
MRPL9	0.407
COQ4	0.405
GEMIN7	0.405
NUBPL	0.405
FASTKD1	0.403
GFPT1	0.401

Global Fraction of Cell Lines Where Essential: 687/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	21/25
breast	33/33
central nervous system	52/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	18/21
liver	19/20
lung	71/75
lymphocyte	14/14
ovary	24/26
pancreas	24/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	5/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	26/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 71
Expression level (log2 read counts): 5.33

Expression Distribution

mitochondrial tyrosyl-tRNA aminoacylation
tyrosyl-tRNA aminoacylation
tyrosine-tRNA ligase activity
tyrosine binding
tRNA aminoacylation for mitochondrial protein translation
mitochondrial RNA metabolic process
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
nuclear body
cellular amino acid metabolic process
mitochondrial matrix
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression