UQCR10

Entrez Summary: N/A
UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-2.86
CI-1040 9.5μM R08 exp472	1.72
Hinokiflavone 12μM R08 exp487	1.72
Tanespimycin 14μM R08 exp527	1.75
iCRT14 30μM R08 exp492	1.8
Ammonium tetrathiomolybdate 10μM R08 exp448	1.99
Mitomycin-C 0.06μM R08 exp503	2.3
ONC212 0.15μM R08 exp513	2.32
CFI-400945 25μM R08 exp469	2.4

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex III assembly
respiratory chain complex III assembly
ubiquinol-cytochrome-c reductase activity
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
cytochrome complex assembly
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization