C17orf89

Gene Information

Official Symbol: NDUFAF8
Official Name: N/ADH:ubiquinone oxidoreductase complex assembly factor 8
Aliases and Previous Symbols: N/A
Entrez ID: 284184
UniProt: A1L188
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). {ECO:0000269|PubMed:27499296}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.86
ABT-702 5μM R06 exp261	-1.76
Nifuroxazide 1μM R01 exp51	-1.72
Hydroxyurea 100μM R07 exp329	1.73
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.84
Ammonium tetrathiomolybdate 10μM R08 exp448	1.87
BI-6727 0.04μM R03 exp98	1.88
SNS-032 15μM R08 exp443	1.9
Tanespimycin 14μM R08 exp527	1.91
Diepoxybutane 3μM R07 exp354	1.95
ONC212 0.15μM R08 exp513	1.96
Thimerosal 0.85μM R08 exp529	2.01
HMS-I2 10μM R06 exp288	2.35
Hinokiflavone 12μM R08 exp487	2.36
Atovaquone 15μM R08 exp451	2.74
PU-H71 1μM R08 exp515	2.78
Artemisinin 50μM R08 exp450	3.16

Gene	Correlation
RNASEH1	0.645
NDUFB5	0.644
YARS2	0.636
NDUFAF7	0.609
MRPS5	0.595
NDUFB11	0.592
NDUFA3	0.586
MRPL21	0.583
C12orf65	0.583
NDUFS7	0.576
GTPBP10	0.575
NDUFAF4	0.573
RPUSD4	0.572
GFM2	0.571
PDSS1	0.567
ECSIT	0.566
SARS2	0.563
HSD17B10	0.558
TMEM242	0.557
BCS1L	0.555
MRPL23	0.548
COX5A	0.547
C10orf2	0.543
MRPS21	0.542
NDUFA2	0.54
MRPS34	0.538
NDUFB6	0.537
SELRC1	0.533
NDUFC2	0.533
FH	0.532
MRPL55	0.532
TMEM126B	0.525
SUPV3L1	0.522
NDUFAF3	0.522
NDUFB3	0.522
TARS2	0.522
COX16	0.521
MRPS6	0.52
AASDHPPT	0.516
NDUFS2	0.515
SLC25A26	0.514
MRPL53	0.514
TPK1	0.514
NDUFB9	0.509
MTG1	0.509
ATP5D	0.508
MRPS16	0.508
KIAA0391	0.508
SCO2	0.508
GFM1	0.506
MRPS26	0.505
MTRF1L	0.505
MRPL15	0.504
NDUFA1	0.504
EARS2	0.504
MTPAP	0.504
QRSL1	0.502
RBFA	0.499
MRPS14	0.498
COX6C	0.497
NDUFA10	0.497
GATC	0.497
TUFM	0.496
NFU1	0.493
NDUFS8	0.493
POLG	0.493
VARS2	0.492
ACAD9	0.492
NDUFAF1	0.491
TEFM	0.489
GRSF1	0.486
NDUFA11	0.484
RTN4IP1	0.482
IBA57	0.482
MRPS33	0.48
MRPL47	0.48
CHCHD4	0.48
PMM2	0.479
ATP5SL	0.478
TRMT61A	0.477
TRMT10A	0.477
FARS2	0.476
RPIA	0.476
MRP63	0.474
MRPL12	0.474
DARS2	0.473
ALG13	0.473
LARS2	0.472
TMEM261	0.471
THG1L	0.47
MIPEP	0.47
ATP5H	0.47
NUBPL	0.469
GLRX5	0.469
PARS2	0.468
NDUFB1	0.465
COQ3	0.465
TRIAP1	0.464
MTO1	0.464
MRPS24	0.463
FASTKD5	0.463
POLG2	0.462
MRPS11	0.461
MRPS9	0.46
MTIF3	0.46
NDUFAF6	0.459
WBSCR16	0.459
TIMM8B	0.458
TRUB2	0.457
DAP3	0.457
MRPS18A	0.456
ATXN10	0.456
COQ2	0.455
FTSJ2	0.455
MTG2	0.454
UQCR10	0.453
ATP5O	0.45
TOMM20	0.448
ATP5A1	0.446
TRNT1	0.445
TIMMDC1	0.445
ALDH18A1	0.443
MRPS2	0.443
FOXRED1	0.441
MRPS25	0.441
DHRSX	0.44
ATP5B	0.44
ALAS1	0.44
MCAT	0.439
LSM10	0.438
COQ7	0.438
TOMM40	0.436
HAUS8	0.432
TOMM22	0.431
ELAC2	0.431
CHCHD1	0.43
VEZT	0.43
AIFM1	0.429
ANGEL2	0.429
UQCC2	0.428
NDUFA6	0.427
MRPL34	0.427
GTF3C6	0.427
ALG8	0.426
GEMIN7	0.426
NDUFB2	0.426
COX7B	0.425
PGM3	0.425
DHX30	0.424
RPUSD3	0.423
AARS2	0.422
DPAGT1	0.422
MRPL46	0.42
MRPL20	0.419
PNPT1	0.418
UHRF1	0.417
MRPS23	0.417
ADSL	0.416
SLC25A19	0.414
ISCA2	0.414
PTRHD1	0.413
MRPL11	0.413
COX17	0.412
UAP1	0.411
PPA2	0.411
ATP5E	0.411
ATP5C1	0.411
MRPL45	0.41
RPE	0.41
RARS2	0.408
MRPS17	0.408
COA5	0.407
UQCRC2	0.406
ALG6	0.406
NDUFB7	0.405
PTDSS1	0.405
HARS2	0.405
MBTPS2	0.404
NARS2	0.404
NDUFA8	0.403
ALG1	0.402
MRPL44	0.402
PET100	0.402
PTCD1	0.401
DOHH	0.401
TEN1	0.401
MINOS1	0.4
EIF3F	0.4

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/26
breast	1/33
central nervous system	2/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4472
Expression level (log2 read counts): 4.67

Expression Distribution

NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial respiratory chain complex assembly
mitochondrion organization
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization