C12orf65

Gene Information

Official Symbol: C12orf65
Official Name: chromosome 12 open reading frame 65
Aliases and Previous Symbols: N/A
Entrez ID: 91574
UniProt: Q9H3J6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-1.77
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.76
Dorsomorphin 5μM R07 exp357	1.7
VER-155008 3.9μM R06 exp301	1.7
BML-284 0.09μM R08 exp460	1.71
Vitamin-D3 40μM R08 exp536	1.74
Chloroquine 32μM R08 exp470	1.75
Oligomycin-A 2μM R00 exp25	1.83
42°C R08 exp539	1.84
Torin1 0.08μM R02 exp82	1.87
CR131-b 0.005μM R08 exp474	1.9
JQ1 0.8μM R08 exp435	1.9
Monensin 0.3μM R08 exp507	1.9
GSK-J4 1.5μM R08 exp441	1.91
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.92
Vemurafenib 6.6μM R08 exp434	1.99
Thimerosal 0.85μM R08 exp529	2.04
ONC212 0.15μM R08 exp513	2.24
Bisphenol A 100μM R06 exp269	2.28
BI-D1870 3.15μM R02 exp66	2.34
HMS-I2 10μM R06 exp288	2.39
PU-H71 1μM R08 exp515	2.46
UM0125461 0.74μM R02 exp84	2.5
TIC10 10μM R08 exp532	2.58

Gene	Correlation
GTPBP10	0.677
RPUSD4	0.642
NDUFA3	0.639
MRPS34	0.637
RNASEH1	0.637
NDUFAF7	0.629
HSD17B10	0.626
MRPS16	0.625
MRPS5	0.623
MRPS26	0.618
SELRC1	0.613
NDUFB5	0.612
MRPL21	0.611
GFM1	0.61
YARS2	0.608
MRP63	0.607
NDUFB11	0.601
MRPS21	0.6
GFM2	0.6
TARS2	0.596
MRPL23	0.594
RBFA	0.593
SCO2	0.588
COX16	0.585
C17orf89	0.583
MRPL53	0.579
MTRF1L	0.578
FASTKD5	0.576
QRSL1	0.575
POLG	0.569
PDSS1	0.562
LARS2	0.562
MRPS6	0.562
COQ2	0.561
EARS2	0.56
MRPS11	0.559
MRPS14	0.559
SLC25A26	0.558
DARS2	0.558
NDUFC2	0.555
VARS2	0.555
FTSJ2	0.554
NDUFA2	0.552
SUPV3L1	0.549
AIFM1	0.549
MRPL55	0.546
COA6	0.545
MTG2	0.544
RARS2	0.541
MIPEP	0.541
BCS1L	0.54
RPUSD3	0.537
MTO1	0.535
NDUFAF4	0.534
SARS2	0.534
MRPL45	0.532
COX15	0.532
MRPL47	0.532
MCAT	0.532
TIMM8B	0.529
PNPT1	0.529
MRPS25	0.528
NARS2	0.527
ECSIT	0.525
MRPS24	0.524
WBSCR16	0.524
POLG2	0.524
METTL17	0.523
GATC	0.523
TEFM	0.523
NDUFS2	0.522
MRPS18A	0.522
COA3	0.521
MRPS10	0.52
PARS2	0.52
NFU1	0.517
NDUFAF3	0.515
AASDHPPT	0.513
MRPL20	0.51
COX6C	0.509
MTIF3	0.509
RTN4IP1	0.508
MRPS33	0.506
MRPL15	0.504
TMEM126B	0.502
PET112	0.502
IBA57	0.502
MRPS9	0.501
CHCHD1	0.501
DAP3	0.499
PET117	0.497
NDUFA1	0.497
TIMMDC1	0.497
MRPS23	0.496
C10orf2	0.495
ATP5SL	0.495
GRSF1	0.493
FASTKD2	0.492
MTPAP	0.492
MTG1	0.491
MRPL12	0.489
CLPP	0.489
TUFM	0.489
SSBP1	0.486
TMEM242	0.484
COQ7	0.484
MRPL11	0.483
KIAA0391	0.482
NUBPL	0.48
ACAD9	0.48
NDUFA11	0.479
TRUB2	0.479
NDUFB6	0.478
NDUFAF5	0.478
TOMM6	0.478
MRPL22	0.475
FOXRED1	0.474
FARS2	0.473
ISCA2	0.472
COQ3	0.472
NDUFS7	0.471
TOMM20	0.47
CHCHD4	0.47
AARS2	0.469
MARS2	0.469
TMEM261	0.469
GLRX5	0.467
NDUFB9	0.466
ALKBH1	0.465
NOA1	0.463
NDUFAF6	0.463
HMGXB3	0.462
HARS2	0.462
NDUFB3	0.461
LSM10	0.46
MRPS12	0.46
TOMM40	0.46
NDUFV1	0.459
MRPS17	0.458
MRPL44	0.456
NDUFB1	0.455
PITRM1	0.454
DHRSX	0.454
TFB1M	0.453
DDX28	0.453
UQCRC2	0.452
DHX30	0.449
MRPS2	0.449
ANGEL2	0.449
MALSU1	0.446
MRPS27	0.445
NDUFA8	0.444
CARS2	0.444
NDUFA6	0.443
POLRMT	0.443
WARS2	0.441
MRPL43	0.441
UQCRQ	0.44
TRIAP1	0.439
COX7B	0.438
TPK1	0.435
MINOS1	0.435
FH	0.434
FASTKD1	0.433
MRPL1	0.432
HIGD2A	0.429
MRPL4	0.428
MRPS7	0.427
DNLZ	0.427
ATP5C1	0.426
COX17	0.425
MRPS35	0.425
NDUFS8	0.423
NDUFS5	0.423
MTERFD2	0.422
GEMIN7	0.422
COX11	0.422
PGM3	0.421
NDUFB7	0.421
ELAC2	0.42
COQ4	0.42
MRPL46	0.419
ALDH18A1	0.418
TOMM22	0.418
MTIF2	0.418
NDUFA10	0.417
MRPL17	0.416
MRPL42	0.412
LRPPRC	0.412
NDUFB2	0.411
MTRF1	0.41
MRPL36	0.409
RNMTL1	0.407
COQ6	0.407
MRPL34	0.406
TIMM17A	0.406
COX5A	0.405
MRPL41	0.405
PTCD3	0.401
ATP5A1	0.401
COX6B1	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2617
Expression level (log2 read counts): 5.95

Expression Distribution

translation release factor activity
mitochondrial large ribosomal subunit
translational termination
cellular protein complex disassembly
protein-containing complex disassembly
translation
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression