NDUFAF3

Gene Information

Official Symbol: NDUFAF3
Official Name: N/ADH:ubiquinone oxidoreductase complex assembly factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 25915
UniProt: Q9BU61
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2009].
UniProt Summary: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000269|PubMed:19463981}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IWR1 50μM R08 exp495	-1.79
MK2206 4μM R08 exp504	1.71
Ribavirin 10μM R01 exp52	1.72
Bafilomycin-A1 0.009μM R08 exp454	1.73
AICAR 240μM R05 exp211	1.76
GSK626616 14μM R08 exp485	1.77
AICAR 240μM R03 exp116	1.79
Phenformin 20μM R05 exp212	1.88
Pterostilbene 16μM R02 exp78	1.9
MK-1775 0.32μM R02 exp75	1.97
Amiloride 100μM R08 exp447	1.99
Cannabidiol 20μM R08 exp466	2.01
Hydroxyurea 100μM R07 exp329	2.02
Chloroquine 32μM R08 exp470	2.07
Tanespimycin 14μM R08 exp527	2.09
UM0129480 7μM R02 exp85	2.09
Arsenate 40μM R06 exp264	2.16
Vemurafenib 6.6μM R02 exp89	2.17
Thimerosal 0.85μM R08 exp529	2.17
UM0125461 0.74μM R02 exp84	2.22
Torin1 0.08μM R02 exp82	2.25
Ammonium tetrathiomolybdate 10μM R08 exp448	2.28
Bleomycin 5μM R08 exp459	2.34
BI-D1870 3.15μM R02 exp66	2.51
Ribavirin 10 to 15μM on day4 R04 exp160	2.52
Genistein 15μM R07 exp360	2.78
HMS-I2 10μM R06 exp288	2.91
Atovaquone 15μM R08 exp451	2.92
Artemisinin 50μM R08 exp450	3.07
Oligomycin-A 2μM R00 exp25	3.15

Gene	Correlation
NDUFB11	0.724
NDUFAF7	0.687
NDUFA2	0.686
NDUFA3	0.675
NDUFS2	0.668
MTO1	0.656
GRSF1	0.655
MTRF1L	0.647
NDUFAF6	0.647
ACAD9	0.641
NDUFA1	0.638
NUBPL	0.63
TIMMDC1	0.621
NDUFB5	0.619
NDUFB9	0.608
NDUFB6	0.606
NDUFC2	0.6
ECSIT	0.591
NDUFS5	0.589
TMEM261	0.582
GTPBP10	0.579
NDUFA8	0.571
NDUFS8	0.569
NDUFA11	0.565
NDUFC1	0.562
FASTKD2	0.559
POLG	0.555
NDUFS7	0.554
QRSL1	0.55
GFM2	0.549
NDUFV1	0.546
CHCHD1	0.543
GFM1	0.542
PET117	0.542
IBA57	0.539
HSD17B10	0.539
FTSJ2	0.537
RNASEH1	0.536
TARS2	0.535
MCAT	0.534
COQ2	0.531
NDUFAF4	0.53
NDUFB10	0.528
POLG2	0.525
NDUFV2	0.524
CARS2	0.523
C17orf89	0.522
NDUFA10	0.521
NDUFB2	0.52
FOXRED1	0.516
RPUSD4	0.516
C12orf65	0.515
NARS2	0.515
POLRMT	0.513
MRPL21	0.512
COQ7	0.512
NDUFAF1	0.511
MRP63	0.507
SELRC1	0.507
LARS2	0.505
NDUFA6	0.504
MRPS25	0.501
MALSU1	0.5
NDUFB7	0.5
NDUFAF5	0.499
MRPL23	0.499
PRIM1	0.494
RTN4IP1	0.494
RPUSD3	0.492
MRPS21	0.489
C10orf2	0.489
PARS2	0.488
NDUFA5	0.487
WARS2	0.486
MTG1	0.485
ATP5SL	0.484
MRPS6	0.484
MTERFD1	0.482
NDUFS1	0.481
MRPS16	0.481
DARS2	0.481
YARS2	0.481
MRPL15	0.48
FARS2	0.48
MRPS34	0.48
COA3	0.48
TFB1M	0.478
MRPL22	0.477
HMGXB3	0.476
PET112	0.476
SSBP1	0.473
RBFA	0.473
SCO2	0.473
MRPL44	0.471
MRPS22	0.471
METTL17	0.471
TEFM	0.47
NFU1	0.468
RMND1	0.464
PTCD3	0.464
WBSCR16	0.464
MRPS2	0.464
PREPL	0.463
MRPS14	0.462
MRPS9	0.462
MRPL3	0.46
VARS2	0.459
MRPL53	0.459
GLRX5	0.459
BCS1L	0.457
NDUFB4	0.457
NDUFA13	0.456
MTG2	0.456
COA6	0.454
MRPS12	0.453
MRPS26	0.452
DAP3	0.451
SUPV3L1	0.45
MRPS5	0.45
MRPL47	0.449
MTERFD2	0.448
MRPL11	0.448
MRPL28	0.447
ERAL1	0.447
EARS2	0.445
NDUFS3	0.443
COQ3	0.442
MRPS33	0.442
SARS2	0.442
PNPT1	0.44
MRPS18A	0.439
COX16	0.437
MRPS18B	0.437
TOMM20	0.436
SFXN4	0.435
MRPL45	0.434
DHX30	0.434
RARS2	0.433
MIPEP	0.433
COX11	0.433
MRPS23	0.432
TUFM	0.431
MRPS24	0.431
MRPL55	0.431
GATC	0.43
KIAA0391	0.43
AARS2	0.428
NSUN4	0.427
MRPS10	0.426
MRPL43	0.424
COX17	0.424
NDUFA9	0.424
TRUB2	0.421
NDUFB3	0.421
MTIF2	0.418
GTPBP6	0.417
COX6C	0.417
C1QBP	0.415
AIFM1	0.415
MRPL4	0.413
MRPS27	0.413
GTPBP8	0.413
FASTKD1	0.412
DDX28	0.412
TFAM	0.408
PDSS1	0.408
MRPL12	0.408
MRPL13	0.406
MTPAP	0.405
MARS2	0.404

Global Fraction of Cell Lines Where Essential: 29/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/26
breast	2/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	2/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1161
Expression level (log2 read counts): 5.06

Expression Distribution

mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex assembly
mitochondrial inner membrane
mitochondrion organization
cellular protein-containing complex assembly
protein-containing complex assembly
protein-containing complex subunit organization