MTG2
Gene Information
- Official Symbol: MTG2
- Official Name: mitochondrial ribosome associated GTPase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 26164
- UniProt: Q9H4K7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. {ECO:0000269|PubMed:17054726, ECO:0000269|PubMed:23396448}.
Pfam Domains GO Terms
Pfam Domains
| FeoB N |
| GTP1 OBG |
| MMR HSR1 |
GO Terms
| regulation of respiratory system process |
| regulation of respiratory gaseous exchange |
| mitochondrial ribosome |
| regulation of mitochondrial translation |
| regulation of mitochondrial gene expression |
| magnesium ion binding |
| ribosome biogenesis |
| GTPase activity |
| regulation of translation |
| mitochondrial matrix |
| GTP binding |
| mitochondrial inner membrane |
| regulation of cellular amide metabolic process |
| ribonucleoprotein complex biogenesis |
| posttranscriptional regulation of gene expression |
| regulation of system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCT251545 20μM R07 exp326 | -2.01 |
| PFI-3 10μM R03 exp144 | -1.76 |
| THZ1 0.06μM R08 exp531 | 1.7 |
| Vemurafenib 6.6μM R08 exp434 | 1.72 |
| GSK-J4 1.5μM R08 exp441 | 1.73 |
| Torin1 0.08μM R02 exp82 | 1.84 |
| CI-1040 9.5μM R08 exp472 | 1.87 |
| Hydroxyurea 100μM R07 exp329 | 2.17 |
| Dorsomorphin 5μM R07 exp357 | 2.19 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TARS2 | 0.698 |
| MRPL21 | 0.659 |
| MRPS34 | 0.637 |
| NARS2 | 0.636 |
| HSD17B10 | 0.633 |
| MRPS6 | 0.629 |
| QRSL1 | 0.624 |
| PARS2 | 0.623 |
| RPUSD4 | 0.621 |
| MRPS5 | 0.619 |
| YARS2 | 0.618 |
| EARS2 | 0.618 |
| MRPL23 | 0.612 |
| GTPBP10 | 0.61 |
| COX16 | 0.608 |
| SCO2 | 0.608 |
| MRPS16 | 0.607 |
| SELRC1 | 0.606 |
| FASTKD5 | 0.605 |
| MRPL47 | 0.603 |
| DAP3 | 0.599 |
| MRPS21 | 0.592 |
| MRP63 | 0.587 |
| AARS2 | 0.576 |
| GFM1 | 0.572 |
| MRPL45 | 0.57 |
| PET112 | 0.567 |
| HARS2 | 0.567 |
| MRPS14 | 0.566 |
| MTPAP | 0.562 |
| MRPS25 | 0.562 |
| LARS2 | 0.561 |
| MRPL53 | 0.558 |
| CHCHD1 | 0.557 |
| MRPS2 | 0.554 |
| KIAA0391 | 0.554 |
| GFM2 | 0.551 |
| SARS2 | 0.55 |
| RNASEH1 | 0.549 |
| MRPL44 | 0.548 |
| COA3 | 0.547 |
| NDUFB11 | 0.546 |
| VARS2 | 0.546 |
| RARS2 | 0.545 |
| C12orf65 | 0.544 |
| RBFA | 0.543 |
| MTG1 | 0.537 |
| MRPS12 | 0.535 |
| MRPS9 | 0.533 |
| MRPS26 | 0.532 |
| BCS1L | 0.531 |
| MRPS24 | 0.527 |
| NDUFA3 | 0.527 |
| WBSCR16 | 0.525 |
| COA6 | 0.523 |
| MRPS18A | 0.522 |
| MALSU1 | 0.521 |
| POLG2 | 0.521 |
| MRPL43 | 0.52 |
| MRPL12 | 0.52 |
| MRPL15 | 0.519 |
| MARS2 | 0.518 |
| NDUFAF7 | 0.512 |
| MRPS35 | 0.512 |
| MRPL55 | 0.511 |
| MRPS10 | 0.51 |
| FTSJ2 | 0.509 |
| PET117 | 0.509 |
| COQ2 | 0.508 |
| MTIF2 | 0.506 |
| MRPL3 | 0.504 |
| SUPV3L1 | 0.504 |
| PDSS1 | 0.503 |
| RNMTL1 | 0.503 |
| SSBP1 | 0.503 |
| GATC | 0.501 |
| NDUFA2 | 0.499 |
| COX7B | 0.496 |
| MIPEP | 0.494 |
| DARS2 | 0.493 |
| TRUB2 | 0.493 |
| METTL17 | 0.49 |
| FARS2 | 0.49 |
| SLC25A26 | 0.49 |
| ECSIT | 0.489 |
| COX6C | 0.488 |
| RPUSD3 | 0.487 |
| TMEM261 | 0.484 |
| POLRMT | 0.484 |
| PNPT1 | 0.483 |
| NDUFC2 | 0.482 |
| MRPL34 | 0.479 |
| COX11 | 0.479 |
| TIMM8B | 0.477 |
| MRPS22 | 0.477 |
| C10orf2 | 0.475 |
| MRPL4 | 0.474 |
| AIFM1 | 0.474 |
| MRPL2 | 0.474 |
| GRSF1 | 0.473 |
| NDUFB5 | 0.47 |
| MRPL20 | 0.47 |
| FASTKD2 | 0.469 |
| WARS2 | 0.468 |
| TOMM20 | 0.468 |
| PTCD1 | 0.466 |
| TEFM | 0.466 |
| MRPS33 | 0.465 |
| DHX30 | 0.465 |
| HMGXB3 | 0.464 |
| ATP5SL | 0.459 |
| MRPS7 | 0.458 |
| MTRF1L | 0.458 |
| NDUFAF3 | 0.456 |
| MTERFD2 | 0.455 |
| C17orf89 | 0.454 |
| PGM3 | 0.454 |
| COA5 | 0.452 |
| TFAM | 0.451 |
| TMEM242 | 0.451 |
| COX17 | 0.451 |
| COQ3 | 0.448 |
| NDUFS2 | 0.447 |
| MRPS23 | 0.446 |
| NDUFAF4 | 0.445 |
| TOMM6 | 0.444 |
| TUFM | 0.443 |
| MRPL37 | 0.442 |
| NDUFB6 | 0.441 |
| CHCHD4 | 0.439 |
| MRPL11 | 0.435 |
| ELAC2 | 0.433 |
| POLG | 0.432 |
| MRPL13 | 0.432 |
| DDX28 | 0.431 |
| NDUFS8 | 0.431 |
| NDUFB9 | 0.431 |
| MTO1 | 0.43 |
| NDUFB7 | 0.427 |
| MTIF3 | 0.427 |
| COQ4 | 0.427 |
| MRPL32 | 0.426 |
| COX15 | 0.426 |
| NDUFA11 | 0.425 |
| IBA57 | 0.425 |
| MRPS28 | 0.425 |
| MRPL1 | 0.424 |
| COQ7 | 0.424 |
| PITRM1 | 0.423 |
| ERAL1 | 0.423 |
| OPA1 | 0.421 |
| NDUFA1 | 0.42 |
| TOMM40 | 0.42 |
| MRPS27 | 0.419 |
| RTN4IP1 | 0.419 |
| COX6B1 | 0.417 |
| ACAD9 | 0.416 |
| CARS2 | 0.416 |
| MRPL33 | 0.415 |
| MCAT | 0.414 |
| PTCD3 | 0.412 |
| MRPL42 | 0.412 |
| COX5A | 0.411 |
| GTPBP8 | 0.409 |
| NDUFC1 | 0.409 |
| RPIA | 0.408 |
| MRPL22 | 0.407 |
| NDUFS7 | 0.406 |
| UQCR10 | 0.405 |
| GTPBP6 | 0.405 |
| MRPL49 | 0.404 |
| MRPL35 | 0.404 |
| MRPL41 | 0.403 |
| NDUFB3 | 0.402 |
| NDUFAF1 | 0.401 |
| PET100 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 33/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 2/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 3/21 |
| liver | 0/20 |
| lung | 5/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 5/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 577
- Expression level (log2 read counts): 5.21
Expression Distribution
MTG2 Expression in NALM6 Cells: 5.21
