TOMM40

Entrez Summary: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: Channel-forming protein essential for import of protein precursors into mitochondria. {ECO:0000269|PubMed:15644312}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC0946 7μM R03 exp151	-1.92
Nocodazole 0.02μM R00 exp23	-1.71
Deferoxamine 11μM R07 exp350	1.7
CI-1040 9.5μM R08 exp472	1.76
Artemisinin 50μM R08 exp450	1.8
42°C R08 exp539	1.86
CR131-b 0.005μM R08 exp474	1.98
Pimelic-diphenylamide-106 5μM R00 exp28	2.26

Global Fraction of Cell Lines Where Essential: 646/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	23/28
bone	23/26
breast	29/33
central nervous system	51/56
cervix	4/4
colorectal	15/17
esophagus	10/13
fibroblast	1/1
gastric	12/16
kidney	18/21
liver	19/20
lung	64/75
lymphocyte	16/16
ovary	20/26
pancreas	22/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	1/1
skin	19/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	28/29
uterus	4/5

Expression Distribution

porin activity
mitochondrial outer membrane translocase complex
pore complex
protein transmembrane transporter activity
protein import into mitochondrial matrix
integral component of mitochondrial outer membrane
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
protein import
macroautophagy
mitochondrial outer membrane
mitochondrial transport
process utilizing autophagic mechanism
autophagy
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
intracellular protein transport
mitochondrion
transmembrane transport
ion transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular catabolic process
establishment of localization in cell
nitrogen compound transport