QRSL1

Gene Information

Official Symbol: QRSL1
Official Name: glutaminyl-tRNA amidotransferase subunit QRSL1
Aliases and Previous Symbols: N/A
Entrez ID: 55278
UniProt: Q9H0R6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03150, ECO:0000269|PubMed:19805282}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	1.77
Mubritinib 0.2μM R01 exp48	1.8
AICAR 240μM R03 exp116	1.92
UM0125461 0.74μM R02 exp84	1.92
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.97
Calcium Ionophore 0.4μM R07 exp342	2
CoCl2 18μM R07 exp346	2.07
CR131-b 0.005μM R08 exp474	2.16
Pterostilbene 16μM R02 exp78	2.18
Hydroxyurea 100μM R07 exp329	2.21
Oligomycin-A 2μM R00 exp25	2.47

Gene	Correlation
HSD17B10	0.749
NARS2	0.736
SELRC1	0.721
PET112	0.719
EARS2	0.719
MRPL21	0.717
YARS2	0.717
DAP3	0.708
MRPS34	0.7
MRPS21	0.692
SCO2	0.689
LARS2	0.685
RARS2	0.685
FTSJ2	0.682
COA3	0.68
MRPS6	0.679
AARS2	0.676
MRPL23	0.67
PARS2	0.666
DARS2	0.666
TARS2	0.664
VARS2	0.657
MRPS14	0.652
GFM2	0.649
MRPS26	0.643
RPUSD4	0.643
FASTKD5	0.641
NDUFB11	0.638
MRPL47	0.637
MRPS5	0.637
MRPS16	0.636
GTPBP10	0.636
MRPS25	0.633
WARS2	0.629
GFM1	0.626
MRP63	0.625
COA6	0.625
WBSCR16	0.625
MTG2	0.624
COX16	0.623
PET117	0.622
COX7B	0.62
MRPL53	0.618
MRPS10	0.611
RPUSD3	0.61
GATC	0.607
BCS1L	0.607
FARS2	0.607
HARS2	0.606
NDUFA3	0.605
MARS2	0.605
MRPL45	0.605
MTG1	0.603
POLG2	0.601
C10orf2	0.6
RBFA	0.6
KIAA0391	0.597
RNASEH1	0.595
MRPS12	0.594
MRPL4	0.589
METTL17	0.586
AIFM1	0.579
MRPS18A	0.579
TEFM	0.579
MRPS9	0.577
SARS2	0.577
NDUFA2	0.577
MTRF1L	0.576
C12orf65	0.575
MRPS22	0.573
CARS2	0.571
NDUFA1	0.569
NDUFAF7	0.566
SUPV3L1	0.565
MRPL3	0.564
COX11	0.563
TRUB2	0.563
POLRMT	0.562
MRPS2	0.562
MRPL22	0.56
MRPL12	0.557
TFB1M	0.556
NDUFS2	0.555
MRPL42	0.554
MRPL15	0.55
NDUFAF3	0.55
POLG	0.547
MRPS23	0.545
RTN4IP1	0.544
MRPL43	0.543
TOMM20	0.543
MTERFD2	0.542
PNPT1	0.541
CHCHD1	0.54
ACAD9	0.539
MRPS27	0.538
GRSF1	0.536
COX15	0.536
MTPAP	0.534
NDUFB9	0.534
MRPL20	0.533
SLC25A26	0.528
HIGD2A	0.527
NDUFC2	0.526
ATP5SL	0.525
DDX28	0.523
PTCD3	0.522
TUFM	0.521
MRPS33	0.52
MCAT	0.52
MIPEP	0.519
MRPL18	0.519
MRPS24	0.518
MRPL49	0.518
MALSU1	0.518
PDSS1	0.516
MRPL33	0.515
NDUFB5	0.515
MRPL55	0.514
MRPL11	0.512
MRPL44	0.511
ATP5C1	0.508
NSUN4	0.505
MTO1	0.504
HMGXB3	0.504
MRPS7	0.503
NDUFB6	0.503
MRPS35	0.503
MRPL17	0.503
C17orf89	0.502
TMEM242	0.501
MTERFD1	0.498
ERAL1	0.496
ATP5D	0.496
TFAM	0.492
MRPL36	0.492
COQ2	0.49
COX17	0.488
NDUFS7	0.488
MTIF2	0.488
NDUFAF4	0.487
SLC25A3	0.487
FASTKD2	0.486
PGM3	0.486
RNMTL1	0.486
TIMMDC1	0.486
COX20	0.484
SSBP1	0.484
IBA57	0.483
ECSIT	0.483
MRPL39	0.48
GTPBP6	0.478
MRPL28	0.477
COX6B1	0.477
NDUFAF6	0.476
MRPS11	0.473
NUBPL	0.472
COA5	0.471
COQ4	0.471
LRPPRC	0.47
FH	0.469
PTCD1	0.468
GTPBP8	0.468
FASTKD1	0.467
TIMM8B	0.467
PITRM1	0.463
COX6C	0.463
NDUFAF1	0.463
NDUFV1	0.462
TMEM261	0.46
NDUFA11	0.46
COQ7	0.46
PDSS2	0.46
MRPL1	0.458
MTIF3	0.458
UQCRC2	0.457
NDUFAF5	0.456
DNLZ	0.453
DHRSX	0.451
MINOS1	0.45
MRPS18B	0.448
NDUFS5	0.448
COQ5	0.447
TFB2M	0.446
CLPP	0.446
ATP5A1	0.444
NDUFB3	0.444
MRPL46	0.443
NDUFC1	0.441
NDUFA8	0.439
COQ3	0.439
MRPS17	0.438
NDUFB7	0.438
PET100	0.437
SCO1	0.436
MRPL38	0.436
MRPL37	0.436
DHX30	0.434
ELAC2	0.432
MRPL41	0.432
C1QBP	0.431
MRPL27	0.431
RPIA	0.43
FOXRED1	0.43
ALDH18A1	0.429
MRPL35	0.429
TOMM22	0.425
OPA1	0.424
NDUFA10	0.424
XPNPEP3	0.423
MRPL13	0.422
MRPL34	0.422
TRMT10C	0.422
COX5A	0.422
TOMM40	0.42
COQ6	0.419
NDUFS8	0.418
LSM10	0.418
MRPL52	0.417
COX19	0.416
UQCR10	0.415
TOMM6	0.412
SLC25A52	0.411
MRPL2	0.408
SLC25A51	0.408
ALG8	0.408
MRPL51	0.407
TRMT61A	0.407
MTRF1	0.407
ICT1	0.404
TMEM126B	0.403
NDUFB4	0.402
MRPL9	0.402
COX18	0.402
MRPL48	0.401
PREPL	0.4

Global Fraction of Cell Lines Where Essential: 36/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/26
breast	3/33
central nervous system	2/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	4/20
lung	5/75
lymphocyte	2/16
ovary	0/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 942
Expression level (log2 read counts): 7.07

Expression Distribution

glutaminyl-tRNAGln biosynthesis via transamidation
amidase activity
glutamyl-tRNA(Gln) amidotransferase complex
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
regulation of protein stability
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression