MRPL18
Gene Information
- Official Symbol: MRPL18
- Official Name: mitochondrial ribosomal protein L18
- Aliases and Previous Symbols: N/A
- Entrez ID: 29074
- UniProt: Q9H0U6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L18p |
GO Terms
| rRNA import into mitochondrion |
| RNA import into mitochondrion |
| rRNA transport |
| 5S rRNA binding |
| mitochondrial ribosome |
| mitochondrial large ribosomal subunit |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| mitochondrial transmembrane transport |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| mitochondrial transport |
| RNA localization |
| nucleobase-containing compound transport |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| transmembrane transport |
| organonitrogen compound biosynthetic process |
| extracellular space |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPL23 | 0.61 |
| MRPS5 | 0.584 |
| MRPS18A | 0.58 |
| MRPS12 | 0.569 |
| MRPS21 | 0.553 |
| MRPS26 | 0.546 |
| COA3 | 0.544 |
| VARS2 | 0.541 |
| MRPS6 | 0.538 |
| MRPS35 | 0.535 |
| DAP3 | 0.533 |
| FARS2 | 0.53 |
| MRPL21 | 0.528 |
| HSD17B10 | 0.526 |
| RARS2 | 0.522 |
| NARS2 | 0.519 |
| QRSL1 | 0.519 |
| MRPS16 | 0.518 |
| DARS2 | 0.514 |
| RPUSD4 | 0.513 |
| YARS2 | 0.513 |
| MRPL47 | 0.511 |
| EARS2 | 0.507 |
| SELRC1 | 0.506 |
| MRPS25 | 0.505 |
| MRPL3 | 0.503 |
| PARS2 | 0.502 |
| KIAA0391 | 0.501 |
| FASTKD5 | 0.5 |
| WBSCR16 | 0.499 |
| SCO2 | 0.499 |
| TRUB2 | 0.498 |
| GFM1 | 0.497 |
| COX7B | 0.496 |
| COX16 | 0.495 |
| MRPL53 | 0.494 |
| MRPL44 | 0.485 |
| MRPS34 | 0.484 |
| PET112 | 0.483 |
| MRPS7 | 0.482 |
| SARS2 | 0.48 |
| SUPV3L1 | 0.48 |
| MRP63 | 0.479 |
| AARS2 | 0.479 |
| MARS2 | 0.478 |
| MRPL20 | 0.477 |
| MRPS2 | 0.474 |
| MTG1 | 0.474 |
| MRPS22 | 0.473 |
| MRPL33 | 0.472 |
| HARS2 | 0.47 |
| PET117 | 0.47 |
| TARS2 | 0.469 |
| RBFA | 0.469 |
| BCS1L | 0.469 |
| GTPBP10 | 0.468 |
| MRPS24 | 0.468 |
| COX15 | 0.467 |
| COX17 | 0.466 |
| GATC | 0.466 |
| MRPS14 | 0.465 |
| COX6B1 | 0.459 |
| MRPL55 | 0.458 |
| FTSJ2 | 0.458 |
| MRPL45 | 0.457 |
| GFM2 | 0.451 |
| PDSS1 | 0.45 |
| MRPL2 | 0.449 |
| METTL17 | 0.449 |
| MTPAP | 0.448 |
| MRPL17 | 0.447 |
| NDUFB11 | 0.446 |
| LARS2 | 0.445 |
| LRPPRC | 0.444 |
| DDX28 | 0.443 |
| MRPL12 | 0.443 |
| COQ4 | 0.442 |
| MRPS10 | 0.435 |
| COA5 | 0.433 |
| MRPS9 | 0.432 |
| MRPL49 | 0.431 |
| TUFM | 0.431 |
| MRPL4 | 0.431 |
| ERAL1 | 0.43 |
| ICT1 | 0.427 |
| MCAT | 0.426 |
| TEFM | 0.424 |
| SLC25A26 | 0.424 |
| MRPL34 | 0.423 |
| IBA57 | 0.421 |
| NDUFA3 | 0.419 |
| UQCRC2 | 0.419 |
| MRPL42 | 0.419 |
| COA6 | 0.418 |
| TRMT10C | 0.417 |
| AIFM1 | 0.416 |
| C10orf2 | 0.415 |
| RPUSD3 | 0.415 |
| MIPEP | 0.415 |
| MRPL52 | 0.414 |
| CARS2 | 0.413 |
| COX11 | 0.407 |
| COQ2 | 0.407 |
| TOMM20 | 0.407 |
| MRPL28 | 0.405 |
| GTPBP6 | 0.405 |
| CLPP | 0.405 |
| NDUFA1 | 0.404 |
| PNPT1 | 0.403 |
| HMGXB3 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 143/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 5/28 |
| bone | 2/26 |
| breast | 10/33 |
| central nervous system | 5/56 |
| cervix | 3/4 |
| colorectal | 7/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 4/16 |
| kidney | 3/21 |
| liver | 5/20 |
| lung | 15/75 |
| lymphocyte | 2/16 |
| ovary | 1/26 |
| pancreas | 4/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 5/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 6/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 270
- Expression level (log2 read counts): 5.74
Expression Distribution
MRPL18 Expression in NALM6 Cells: 5.74
