UQCRC2

Entrez Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].
UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sucrose 20000μM R06 exp298	-1.87
Bisphenol S 100μM R08 exp458	-1.84
Daidzin 10μM R06 exp280	-1.84
IL-3 9ng/ml R08 exp493	-1.76
L-74142 5μM R03 exp131	-1.7
Aphidicolin 0.4μM R08 exp440	1.7
GSK-J4 1.5μM R08 exp441	1.72
Nutlin-3A 1.6μM R06 exp294	1.75
UM0125461 0.74μM R02 exp84	1.75
ONC212 0.15μM R08 exp513	1.8
Hydroxyurea 100μM R07 exp329	1.9
AICAR 240μM R05 exp211	1.96
TIC10 10μM R08 exp532	2.04
Mitomycin-C 0.06μM R08 exp503	2.19
AICAR 240μM R03 exp116	2.34
Ammonium tetrathiomolybdate 10μM R08 exp448	3.77

Global Fraction of Cell Lines Where Essential: 133/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	7/28
bone	4/26
breast	6/33
central nervous system	3/56
cervix	1/4
colorectal	5/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	4/21
liver	6/20
lung	15/75
lymphocyte	3/16
ovary	1/26
pancreas	3/24
peripheral nervous system	2/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	0/5

Expression Distribution

Peptidase M16
Peptidase M16 C

mitochondrial processing peptidase complex
protein processing involved in protein targeting to mitochondrion
mitochondrial protein processing
mitochondrial respiratory chain complex IV
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
endopeptidase activity
protein localization to mitochondrion
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
metalloendopeptidase activity
respiratory electron transport chain
oxidative phosphorylation
protein processing
cellular respiration
electron transport chain
ATP metabolic process
mitochondrial transport
protein maturation
energy derivation by oxidation of organic compounds
protein-containing complex binding
protein targeting
mitochondrial inner membrane
generation of precursor metabolites and energy
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
oxidation-reduction process
intracellular protein transport
response to drug
mitochondrion
proteolysis
phosphorylation
protein transport
intracellular transport
peptide transport
amide transport