UQCRQ

Entrez Summary: This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008].
UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
L-BMAA 500 to 750μM on day4 R04 exp185	-1.76
PU-H71 1μM R08 exp515	1.71
Hinokiflavone 12μM R08 exp487	1.72
Mubritinib 0.2μM R02 exp65	1.75
ONC212 0.15μM R08 exp513	1.83
CI-1040 9.5μM R08 exp472	2.02
GSK-J4 1.5μM R08 exp441	2.25
Ammonium tetrathiomolybdate 10μM R08 exp448	3.43

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Expression Distribution

subthalamus development
pyramidal neuron development
pyramidal neuron differentiation
ubiquinol-cytochrome-c reductase activity
pons development
thalamus development
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
hypothalamus development
cerebellar Purkinje cell layer development
forebrain neuron development
cerebellar cortex development
forebrain neuron differentiation
forebrain generation of neurons
diencephalon development
central nervous system neuron development
hippocampus development
midbrain development
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
cerebellum development
limbic system development
respiratory electron transport chain
metencephalon development
oxidative phosphorylation
hindbrain development
cellular respiration
pallium development
central nervous system neuron differentiation
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
telencephalon development
forebrain development
mitochondrial inner membrane
generation of precursor metabolites and energy
brain development
head development
neuron development
oxidation-reduction process