MRPL23

Gene Information

Official Symbol: MRPL23
Official Name: mitochondrial ribosomal protein L23
Aliases and Previous Symbols: N/A
Entrez ID: 6150
UniProt: Q16540
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SGC0946 7μM R03 exp151	-1.85
LLY-283 2.6μM R06 exp290	1.75
Benzoate 20000μM R08 exp456	1.76
Oligomycin-A 2μM R00 exp25	1.77
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.79
42°C R08 exp539	1.8
Tanespimycin 14μM R08 exp527	1.81
Ammonium tetrathiomolybdate 10μM R08 exp448	1.83
Sulforaphane 9μM R08 exp526 no dilution day6	1.94
Arsenate 40μM R06 exp264	1.96
Tubacin 1.6μM R07 exp416	2.04
TIC10 10μM R08 exp532	2.15
ONC212 0.15μM R08 exp513	2.19
Dorsomorphin 5μM R07 exp357	2.29
Deferoxamine 11μM R07 exp350	2.35
Aphidicolin 0.4μM R08 exp440	2.46
CoCl2 18μM R07 exp346	2.6
GSK-J4 1.5μM R08 exp441	3.05
Hydroxyurea 100μM R07 exp329	3.34

Gene	Correlation
YARS2	0.74
HSD17B10	0.735
MRPL21	0.733
PARS2	0.709
MRPS14	0.709
DAP3	0.699
TARS2	0.699
MRPS5	0.699
MRPS34	0.697
FASTKD5	0.694
MRPS21	0.694
MRPL53	0.693
MRPS6	0.692
MRP63	0.692
RPUSD4	0.688
NARS2	0.675
VARS2	0.675
MRPS18A	0.671
QRSL1	0.67
COX16	0.661
MRPS26	0.65
GFM1	0.647
SELRC1	0.645
SUPV3L1	0.645
SARS2	0.644
MRPL47	0.635
MRPS16	0.634
RBFA	0.633
DARS2	0.63
WBSCR16	0.63
MRPS2	0.63
RARS2	0.629
SCO2	0.626
GTPBP10	0.625
MTPAP	0.623
KIAA0391	0.621
EARS2	0.62
HARS2	0.616
MTG2	0.612
MRPS12	0.611
LARS2	0.611
COA3	0.61
MRPL18	0.61
FTSJ2	0.609
AARS2	0.605
C10orf2	0.603
MRPS25	0.602
NDUFA3	0.6
MTG1	0.597
GATC	0.597
NDUFB11	0.597
GFM2	0.595
C12orf65	0.594
COX7B	0.594
MRPL12	0.594
PET112	0.593
COX17	0.591
MRPL15	0.59
MARS2	0.589
FARS2	0.589
BCS1L	0.588
MRPL20	0.587
MRPL44	0.585
MRPS24	0.584
TRUB2	0.583
MRPL45	0.583
MRPL3	0.582
MRPS9	0.581
TEFM	0.581
MRPS10	0.574
SLC25A26	0.571
TUFM	0.57
RNASEH1	0.568
MRPL55	0.567
MRPL34	0.563
PDSS1	0.561
MRPS35	0.558
MIPEP	0.557
NDUFAF7	0.557
COQ2	0.555
C17orf89	0.548
MRPS33	0.547
MRPS23	0.544
ELAC2	0.543
MRPL4	0.542
MRPL33	0.542
DNLZ	0.541
IBA57	0.54
DHRSX	0.539
COX11	0.539
RPUSD3	0.534
MRPS7	0.534
TOMM20	0.533
PGM3	0.53
COA5	0.53
RNMTL1	0.529
COA6	0.528
MRPL43	0.528
MTRF1L	0.527
ATP5D	0.525
PNPT1	0.524
MTERFD2	0.523
MRPL39	0.523
UQCRC2	0.522
MRPS11	0.521
CHCHD4	0.521
METTL17	0.521
COX15	0.52
TMEM242	0.517
NDUFC2	0.516
ATP5A1	0.516
MRPL52	0.516
COX6B1	0.515
TOMM40	0.515
NDUFB5	0.514
MRPL42	0.514
MRPL2	0.512
MRPL11	0.51
AASDHPPT	0.509
MRPL36	0.509
POLRMT	0.506
COQ3	0.505
OPA1	0.504
AIFM1	0.502
TRIAP1	0.501
MRPL41	0.5
NDUFB6	0.499
NDUFAF3	0.499
MRPL22	0.498
NDUFA1	0.498
TIMM8B	0.496
ATP5C1	0.494
TFAM	0.493
MRPL46	0.493
CHCHD1	0.491
TAMM41	0.49
COX5A	0.489
LSM10	0.489
POLG2	0.488
NDUFAF4	0.488
PET117	0.487
PPA2	0.485
RPIA	0.484
PITRM1	0.482
UQCRQ	0.482
TPK1	0.479
HMGXB3	0.477
ALG8	0.476
MRPS22	0.476
NDUFA2	0.475
POLG	0.475
MRPL17	0.474
ACAD9	0.471
TRMT61A	0.47
COX6C	0.47
NDUFA11	0.469
COQ7	0.469
MRPL27	0.468
TAZ	0.467
MCAT	0.466
UQCR10	0.463
DHX30	0.463
MTERFD1	0.462
ATP5SL	0.46
MRPL49	0.46
MRPS28	0.459
WARS2	0.459
LRPPRC	0.459
TRMT10C	0.457
NDUFS7	0.457
PMM2	0.457
MALSU1	0.457
HIGD2A	0.457
MTIF3	0.456
TRMT10A	0.456
FH	0.455
CRLS1	0.453
PTCD3	0.453
MRPL38	0.453
CLPP	0.452
PPCS	0.452
ALG6	0.45
ALDH18A1	0.45
HCCS	0.45
UQCC2	0.449
NDUFAF5	0.448
GLRX5	0.446
NDUFV1	0.446
SRD5A3	0.445
ATP5B	0.444
MRPL13	0.444
MRPS27	0.441
PTCD1	0.439
RTN4IP1	0.438
NDUFB1	0.438
FASTKD2	0.438
COQ4	0.437
ATXN10	0.436
COQ5	0.434
ROMO1	0.433
ERAL1	0.433
TOMM22	0.432
MTIF2	0.43
COQ6	0.43
NDUFB3	0.43
NDUFAF1	0.428
ALG1	0.428
PTDSS1	0.428
ICT1	0.426
MBTPS2	0.426
SSBP1	0.425
DOHH	0.424
TFB1M	0.423
MRPL28	0.423
TIMM17A	0.423
COX19	0.421
LONP1	0.421
BRWD1	0.42
DPAGT1	0.42
ECSIT	0.42
DDX28	0.419
ATP5H	0.419
DOLK	0.418
TMEM126B	0.417
PRKRIR	0.417
PMVK	0.417
NDUFB9	0.416
RFT1	0.416
PTPMT1	0.415
MRPS17	0.415
UAP1	0.415
MRPL32	0.413
ALG5	0.413
NDUFS2	0.412
ISCA2	0.411
CARS2	0.411
TOMM6	0.41
MRPL51	0.406
GRSF1	0.406
TFB2M	0.406
NDUFC1	0.405
METTL1	0.404
NFU1	0.402
CYCS	0.402
GTPBP8	0.402

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	2/26
breast	2/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 416
Expression level (log2 read counts): 4.61

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
fibrillar center
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression