TMEM126B

Entrez Summary: This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017].
UniProt Summary: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. {ECO:0000269|PubMed:24191001}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MKC9989 10μM R03 exp133	-1.91
Parthenolide 2.5μM R05 exp238	-1.73
HMS-I2 10μM R06 exp288	1.7
R-DABN 8μM R03 exp111	1.7
Citral 75μM R06 exp275	1.77
CI-1040 9.5μM R08 exp472	1.81
Trimetrexate 0.03μM R08 exp535	1.81
MK2206 4μM R08 exp504	1.84
GSK-J4 1.5μM R08 exp441	1.87
Artemisinin 50μM R08 exp450	1.92
Vinblastine 0.2μM R03 exp108	1.96
Ammonium tetrathiomolybdate 10μM R08 exp448	2
Thimerosal 0.85μM R08 exp529	2.15
iCRT14 30μM R08 exp492	2.2
ONC212 0.15μM R08 exp513	2.26
SNS-032 15μM R08 exp443	2.27
Arsenic trioxide 60μM R08 exp449	2.37
Monensin 0.3μM R08 exp507	2.44
UM0129480 7μM R02 exp85	2.55
Atovaquone 15μM R08 exp451	2.56
Tanespimycin 14μM R08 exp527	2.68
Taxol 0.004μM R03 exp103	2.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial respiratory chain complex assembly
mitochondrial inner membrane
mitochondrion organization
molecular function
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization