R-DABN 8μM R03 exp111

Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine

Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit

Compound References

PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine
Synonyms: N/A
CAS #: 18741-85-0
PubChem CID: 20571
IUPAC: 1-(2-aminonaphthalen-1-yl)naphthalen-2-amine
INCHI Name: InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
INCHI Key: DDAPSNKEOHDLKB-UHFFFAOYSA-N
Molecular Weight: 284.4
Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
Isomeric SMILES: N/A
Molecular Formula: C20H16N2

Compound Supplier

Supplier Name: Chem-Impex International
Catalog #: 24622
Lot #: 001702-20130307

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H16N2 285.13862; found 285.13901

Dose Response Curve

Dose response curve not available.

Screen Summary

Round: 03
Dose: 8µM
Days of incubation: 8
Doublings: 1.9
Numbers of reads: 13572519

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/102	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
MS4A13	-2.92	0.52
CCDC42B	-2.67	0.19
GET4	-2.59	0.19
OTOS	-2.40	0.24
AQR	-2.38	0.50
KRTAP5-4	-2.28	0.43
HHLA3	-2.28	0.35
TSC2	-2.25	0.35
ZBTB48	-2.22	0.35
AHCTF1	-2.22	0.50
RANBP1	-2.21	0.35
TRAPPC4	-2.19	0.35
WDR7	-2.18	0.35
FAM120A	-2.15	0.35
DNA2	-2.13	0.52
C5orf45	-2.12	0.35
RGMA	-2.11	0.35
CHMP1A	-2.10	0.46
PLEC	-2.10	0.35
MED12	-2.07	0.55
COG4	-2.07	0.35
NAPA	-2.06	0.50
TAS2R40	-2.06	0.35
FAM227A	-2.06	0.46
DTYMK	-2.01	0.63
PSMB2	-2.00	0.63
CRISPLD2	-1.96	0.46
SLC22A14	-1.96	0.52
CDC7	-1.95	0.46
CMIP	-1.95	0.46
FBXL18	3.29	<0.01
RNF216	3.30	<0.01
HERPUD2	3.31	<0.01
CYTH3	3.32	<0.01
AP5Z1	3.32	<0.01
AMZ1	3.33	<0.01
FERD3L	3.34	<0.01
RSPH10B	3.38	<0.01
TMEM196	3.50	<0.01
HOXA2	3.58	<0.01
PRR15	3.59	<0.01
RSPH10B2	3.62	<0.01
PSPH	3.70	<0.01
MEOX2	3.75	<0.01
ADCYAP1R1	3.75	<0.01
FNTB	3.75	<0.01
RBM14-RBM4	3.80	<0.01
RBM14	3.87	<0.01
USP42	4.18	<0.01
ITGB8	4.25	<0.01
CDC20	4.51	<0.01
MAD2L1BP	5.07	<0.01
MAD2L1	5.14	<0.01
ZWILCH	5.22	<0.01
BUB1B	5.53	<0.01
MAD1L1	5.56	<0.01
BUB3	5.89	<0.01
ZW10	8.03	<0.01
TRIP13	8.19	<0.01
KNTC1	8.27	<0.01

Screen	Correlation	Plot
Rotenone 2μM R00 exp33	0.256	View
SB743921 0.001μM R05 exp244	0.227	View
Vinblastine 0.015μM R05 exp208	0.169	View
Vinblastine 0.2μM R03 exp108	0.106	View
Nocodazole 0.1μM R03 exp94	0.286	View
DABN racemic mixture R03 exp93	0.262	View
Nocodazole 0.2μM R00 exp24	0.245	View
HMS-I1 10μM R06 exp256	0.189	View
Nocodazole 0.2μM R02 exp64	0.18	View
BI-6727 0.04μM R03 exp98	0.121	View
BI-2536 0.02μM R03 exp96	0.071	View
GSK461364A 0.1μM R03 exp126	0.064	View
DABN 20μM R00 exp17	0.053	View

GO Term	Fold Change	Genes
mitotic spindle checkpoint signaling	177.63	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
mitotic spindle assembly checkpoint signaling	177.63	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
spindle assembly checkpoint signaling	177.63	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of mitotic sister chromatid segregation	160.44	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of mitotic sister chromatid separation	160.44	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
spindle checkpoint signaling	152.45	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,CDC20
negative regulation of metaphase/anaphase transition of cell cycle	150.72	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of chromosome segregation	150.72	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of chromosome separation	150.72	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of sister chromatid segregation	142.62	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,CDC20
negative regulation of mitotic metaphase/anaphase transition	142.62	KNTC1,TRIP13,ZW10,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
negative regulation of nuclear division	108.12	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20
regulation of mitotic sister chromatid segregation	93.84	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP
regulation of mitotic sister chromatid separation	85.75	TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20
regulation of chromosome separation	75.70	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20
regulation of mitotic metaphase/anaphase transition	62.09	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20
regulation of metaphase/anaphase transition of cell cycle	60.07	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20
regulation of mitotic nuclear division	51.96	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20,HOXA13
regulation of nuclear division	42.22	KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20,HOXA13

R-DABN 8μM R03 exp111

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results