AQR

Gene Information

Official Symbol: AQR
Official Name: aquarius intron-binding spliceosomal factor
Aliases and Previous Symbols: N/A
Entrez ID: 9716
UniProt: O60306
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. {ECO:0000269|PubMed:16949364}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
R-DABN 8μM R03 exp111	-2.38
Staurosporine 0.02μM R08 exp524	-1.78
Palbociclib 1μM R07 exp382	-1.76
Rifampicin 1μM R00 exp31	1.71
A-366 10μM R03 exp115	1.73
VE-822 0.04μM R06 exp300	1.74
Isoniazid 100μM R08 exp494	1.76
proTAME 5μM R04 exp187	1.76
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.77
DABN 2μM R00 exp16	1.84
Pyrazinamide 100μM R08 exp516	1.97
3-Bromopyruvate 7μM R04 exp175	2.03
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.09
JQ1 0.01μM R03 exp130	2.23
Apcin 50 to 100μM on day4 R04 exp176	2.3
Cycloheximide 0.02μM R00 exp14	2.71

Gene	Correlation
TBC1D3H	0.583
TBC1D3F	0.553
TBC1D3G	0.551
PRIM1	0.545
TCEB3C	0.544
TCEB3CL	0.531
CHD4	0.531
POLR2J3	0.525
CCNA2	0.523
C14orf93	0.523
PSMB2	0.521
VASN	0.519
TCEB3CL2	0.518
TYMS	0.516
CACTIN	0.514
TFIP11	0.508
PSMA6	0.508
SUPT5H	0.508
TUBA8	0.507
MT1E	0.506
TICRR	0.504
SNRPA1	0.503
TBC1D3I	0.503
TBC1D3E	0.502
TBC1D3L	0.501
TBC1D3K	0.501
SYT9	0.5
ITGA2B	0.499
DTL	0.497
MED12	0.496
PSMB4	0.496
CMYA5	0.493
VPS28	0.493
PSMD3	0.492
S1PR4	0.488
DISP2	0.488
RRP7A	0.487
SLC4A1	0.487
RPL35	0.485
COPG1	0.484
TBC1D3	0.484
RAD51	0.482
UTP3	0.481
AATF	0.481
TBC1D3C	0.48
CHAF1A	0.48
ART5	0.479
NPIPB5	0.478
C1QTNF9B	0.477
PAN2	0.474
GAR1	0.474
AAMP	0.473
HINFP	0.473
RPS12	0.472
MYO1H	0.47
PSAP	0.467
FAM25B	0.465
ORC1	0.465
ATP6AP1	0.464
CDC73	0.464
DDTL	0.463
RPSA	0.463
SF3A1	0.461
MED29	0.459
NOL12	0.459
SLC38A7	0.459
RBBP5	0.458
OGFR	0.457
DNTTIP2	0.457
KRT78	0.456
LRR1	0.455
HIST1H2BE	0.455
IGFN1	0.454
SLC6A17	0.454
MED14	0.454
CBWD3	0.454
RRP15	0.453
NUP160	0.453
PHF2	0.453
PSMC5	0.452
PLK1	0.452
CLN6	0.452
SUPT6H	0.451
TTC1	0.451
RPS2	0.45
PSMC6	0.448
CDCA3	0.447
RPL6	0.447
POLR2L	0.446
CBWD5	0.446
NUP153	0.446
DHX38	0.445
TP53TG3D	0.445
ISCU	0.445
CNPY3	0.444
NAPA	0.444
HAP1	0.443
COPE	0.443
IK	0.443
SSH2	0.443
PSMD11	0.442
NUPL1	0.441
PAN3	0.441
RANBP2	0.441
COPA	0.44
EXOSC9	0.438
CDC6	0.437
DIDO1	0.437
POLR2F	0.437
COPB1	0.436
BYSL	0.435
MED17	0.435
TTC31	0.434
ORC6	0.433
ELMOD3	0.432
PCF11	0.432
SH3BP1	0.432
TWISTNB	0.432
XAB2	0.431
UBAP1	0.43
NOL10	0.43
CHMP2A	0.429
TP53TG3	0.428
TP53TG3B	0.428
RPS5	0.427
FCN2	0.427
TP53TG3C	0.427
ZFAND5	0.426
GID4	0.426
C2orf27B	0.426
ATP6V0C	0.426
CEP192	0.425
POLE	0.423
ANKLE1	0.423
CCDC94	0.423
CBWD6	0.421
HIST2H3C	0.421
HIST2H3A	0.42
SFPQ	0.42
ZNF830	0.42
CDH24	0.42
PSMC2	0.419
ATP1A3	0.418
DDX56	0.418
RAD21	0.418
SCAF1	0.417
TRIM52	0.416
PAF1	0.415
WDR87	0.415
PSMD7	0.415
PWP2	0.415
CDC45	0.415
TRAIP	0.415
FANCM	0.414
GPRIN2	0.414
RPL30	0.413
NUP85	0.413
PARP3	0.413
RPS7	0.412
DDX47	0.412
NUP54	0.412
AKIRIN2	0.411
PSMD2	0.411
MYB	0.41
GOLGA6L3	0.41
AAAS	0.41
RPLP1	0.409
EGR2	0.409
FBXW9	0.409
PDE4DIP	0.409
RNF113A	0.409
SEC13	0.408
ITGAX	0.408
PALB2	0.408
ZNF541	0.408
APC2	0.408
NOP16	0.408
NUF2	0.408
POLR2A	0.407
SNIP1	0.407
SF3A2	0.406
POLD1	0.405
EXOSC3	0.405
POLA1	0.405
RRN3	0.405
RPL14	0.404
EXD1	0.404
SCGB1C1	0.404
GOLGA6A	0.404
GOLGA6L4	0.404
HIVEP3	0.403
POLA2	0.402
RPL37A	0.402
AHCTF1	0.401
NARFL	0.4
RRP9	0.4
ACSF2	0.4
CTAGE4	0.4
ATP6V1C1	0.4

Global Fraction of Cell Lines Where Essential: 424/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	8/28
blood	23/28
bone	13/26
breast	21/33
central nervous system	28/56
cervix	1/4
colorectal	13/17
esophagus	8/13
fibroblast	1/1
gastric	8/16
kidney	12/21
liver	9/20
lung	37/75
lymphocyte	12/16
ovary	18/26
pancreas	15/24
peripheral nervous system	12/16
plasma cell	9/15
prostate	1/1
skin	11/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	5/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 349
Expression level (log2 read counts): 7.3

Expression Distribution

U2-type catalytic step 2 spliceosome
RNA helicase activity
transcription-coupled nucleotide-excision repair
catalytic step 2 spliceosome
spliceosomal complex
nucleotide-excision repair
mRNA binding
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
DNA repair
mRNA metabolic process
DNA metabolic process
cellular response to DNA damage stimulus
RNA processing
RNA binding
ATP binding
RNA metabolic process
cellular response to stress
membrane
gene expression