APC2

Gene Information

Official Symbol: APC2
Official Name: APC regulator of WNT signaling pathway 2
Aliases and Previous Symbols: N/A
Entrez ID: 10297
UniProt: O95996
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017].
UniProt Summary: Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
ART5	0.476
DHX38	0.469
RPL35	0.462
POLR2J3	0.455
C1QTNF9B	0.453
TBC1D3F	0.448
PALB2	0.444
TBC1D3H	0.442
LOC643669	0.439
FAM25B	0.423
NUP85	0.423
TCEB3CL2	0.422
AKIRIN2	0.422
KPNB1	0.421
PSMB2	0.418
KCTD17	0.418
GOLGA6L4	0.417
SLC6A17	0.414
SH3BP1	0.41
AQR	0.408
CMYA5	0.408
GOLGA6L3	0.407
RRP7A	0.406
DDTL	0.405
RNF113A	0.402
MED14	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2312
Expression level (log2 read counts): 1.77

Expression Distribution

Screen	Score
IU1-47 25μM R04 exp182	1.7
Cabazitaxel 0.001μM R05 exp223	1.82
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.1

SAMP
Arm
Suppressor APC
APC basic

gamma-catenin binding
beta-catenin destruction complex
lamellipodium membrane
negative regulation of microtubule depolymerization
regulation of microtubule depolymerization
catenin complex
filamentous actin
negative regulation of microtubule polymerization or depolymerization
cytoplasmic microtubule
intercellular bridge
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
regulation of microtubule polymerization or depolymerization
actin filament
regulation of protein depolymerization
postsynapse
beta-catenin binding
cell fate specification
activation of GTPase activity
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
microtubule cytoskeleton
midbody
negative regulation of canonical Wnt signaling pathway
regulation of microtubule cytoskeleton organization
negative regulation of Wnt signaling pathway
positive regulation of protein catabolic process
regulation of microtubule-based process
microtubule binding
cell fate commitment
regulation of canonical Wnt signaling pathway
regulation of supramolecular fiber organization
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
negative regulation of organelle organization
regulation of protein catabolic process
positive regulation of GTPase activity
cell surface receptor signaling pathway involved in cell-cell signaling