DHX38
Gene Information
- Official Symbol: DHX38
- Official Name: DEAH-box helicase 38
- Aliases and Previous Symbols: N/A
- Entrez ID: 9785
- UniProt: Q92620
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 702
- Expression level (log2 read counts): 6.77
DHX38 Expression in NALM6 Cells: 6.77
