LJH685 5μM R02 exp73 [The Human Chemical-Genetic Interaction Map Project]

Inhibits p90 ribosomal S6 kinase (RSK)

Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: 2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol
Synonyms: N/A
CAS #: 1627710-50-2
PubChem CID: 73010393
IUPAC: 2,6-difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]phenol
INCHI Name: InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3
INCHI Key: IKUFKDGKRLMXEX-UHFFFAOYSA-N
Molecular Weight: 381.4
Canonical SMILES: CN1CCN(CC1)C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F
Isomeric SMILES: N/A
Molecular Formula: C22H21F2N3O

Compound Supplier

Supplier Name: Med Chem Express
Catalog #: HY-19712
Lot #: 20222

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H21F2N3O 382.17255; found 382.17299

Dose Response Curve

Platform ID: LJH685
Min: -6.5646; Max: 16.3818

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 02
Dose: 5µM
Days of incubation: 8
Doublings: 6.9
Numbers of reads: 12379255

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
MOGAT1	-2.68	0.12
CDIPT	-2.65	0.42
ERI3	-2.44	0.34
SPATA31E1	-2.27	0.34
IQCJ	-2.26	0.34
VHL	-2.25	0.34
RBM14	-2.21	0.34
PMVK	-2.20	0.34
KDSR	-2.19	0.34
TTI1	-2.18	0.34
GMPPB	-2.18	0.63
RBM14-RBM4	-2.18	0.34
STARD8	-2.17	0.34
ODF4	-2.13	0.34
PCDHB10	-2.12	0.34
CXorf64	-2.08	0.54
MAP9	-2.08	0.46
GRM7	-2.07	0.34
APOM	-2.07	0.34
MMGT1	-2.07	0.46
TRIM44	-2.06	0.46
ANKRD11	-2.04	0.48
ORAOV1	-2.04	0.55
FARSA	-2.03	0.73
FAF2	-2.00	0.57
DYSF	-1.98	0.45
CCDC101	-1.97	0.54
ZCRB1	-1.97	0.54
RABGGTB	-1.96	0.54
MTX1	-1.94	0.54
CECR2	1.93	0.59
BAGE4	1.95	0.89
BAGE5	1.95	0.89
BAGE2	1.95	0.89
BAGE	1.95	0.89
BAGE3	1.95	0.89
DEFB136	1.95	0.63
C1orf112	1.98	0.60
PLRG1	1.98	0.73
SMAD6	1.99	0.59
ATF6	2.01	0.72
OR4K17	2.01	0.59
DNAJC10	2.03	0.59
ZNF335	2.10	0.60
UBR4	2.10	0.59
DHX38	2.11	0.89
ZFYVE1	2.14	0.59
MPZL1	2.16	0.58
TERF2	2.18	0.59
ALKBH2	2.18	0.59
KIF11	2.19	0.89
ANXA3	2.19	0.58
RAP1B	2.20	0.59
ACTB	2.23	0.59
RPS3	2.28	0.60
DDX46	2.29	0.83
USP17L19	2.45	0.74
SYT12	2.65	0.09
EIF3G	2.80	0.09
NUP205	2.84	0.12

Last modified: 2026/01/15 21:36
by 127.0.0.1